Apolipoprotein E Gene Polymorphisms Are Associated with Primary Hyperuricemia in a Chinese Population

被引:9
|
作者
Wu, Jie [1 ,2 ]
Qiu, Ling [1 ,2 ]
Guo, Xiu-zhi [1 ,2 ]
Xu, Tao [3 ,4 ]
Cheng, Xin-qi [1 ,2 ]
Zhang, Lin [1 ,2 ]
Li, Peng-chang [1 ,2 ]
Di, Qian [1 ,2 ]
Wang, Qing [5 ]
Ni, Lan [5 ]
Zhu, Guang-jin [6 ,7 ]
机构
[1] Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Clin Lab, Beijing 100021, Peoples R China
[2] Chinese Acad Med Sci, Beijing 100730, Peoples R China
[3] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Epidemiol & Stat, Beijing 100730, Peoples R China
[4] Peking Union Med Coll, Beijing 100021, Peoples R China
[5] Ningxia Med Univ, Gen Hosp, Ctr Med Expt, Yinchuan, Peoples R China
[6] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Pathophysiol, Beijing 100730, Peoples R China
[7] Peking Union Med Coll, Beijing 100021, Peoples R China
来源
PLOS ONE | 2014年 / 9卷 / 10期
关键词
SERUM URIC-ACID; C-REACTIVE PROTEIN; RISK-FACTORS; E GENOTYPES; CARDIOVASCULAR RISK; METABOLIC SYNDROME; LIPID PARAMETERS; GOUT; HYPERTENSION; DISEASE;
D O I
10.1371/journal.pone.0110864
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Objective: Primary hyperuricemia, an excess of uric acid in the blood, is a major public health problem. In addition to the morbidity that is attributable to gout, hyperuricemia is also associated with metabolic syndrome, hypertension, and cardiovascular disease. This study aims to assess the genetic associations between Apolipoprotein E (APOE) polymorphisms and hyperuricemia in a Chinese population. Methods: A total of 770 subjects (356 hyperuricemic cases and 414 normouricemic controls) were recruited from the Ningxia Hui Autonomous Region, China. A physical examination was performed and fasting blood was collected for biochemical tests, including determination of the levels of serum lipid, creatinine, and uric acid. Multi-ARMS PCR was applied to determine the APOE genotypes, followed by an investigation of the distribution of APOE genotypes and alleles frequencies in the controls and cases. Results: The frequencies of the APOE-epsilon 2 epsilon 3 genotype (17.70% vs. 10.39%, P=0.003) and the APOE-epsilon 2 allele (10.53% vs. 5.80%, P=0.001) were significantly higher in the hyperuricemic group than in the normouricemic group. Furthermore, male cases were more likely to have the APOE-epsilon 2 epsilon 3 genotype and APOE-epsilon 2 allele, compared with male controls. In both Han and Hui subjects, cases were more likely to have the APOE-epsilon 2 epsilon 3 genotype and the APOE-epsilon 2 allele compared with controls. Furthermore, multivariate logistic regression showed that carriers of the APOE-epsilon 2 epsilon 3 genotype (P=0.001, OR=2.194) and the epsilon 2 allele (P = 0.001, OR = 2.099) were significantly more likely to experience hyperuricemia than carriers of the epsilon 3/epsilon 3 genotype and the epsilon 3 allele after adjustment for sex, body mass index (BMI), diastolic blood pressure (DBP), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), creatinine (Cr) and fasting blood glucose(FBG). Conclusions: The APOE-epsilon 2 epsilon 3 genotype and the APOE-epsilon 2 allele are associated with serum uric acid levels in Chinese subjects, indicating that individuals carrying the APOE-epsilon 2 allele have a higher risk of hyperuricemia than non-carriers.
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页数:9
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