Pd-Catalyzed Oxidative ortho-C-H Borylation of Arenes

被引：160

作者：

Dai, Hui-Xiong ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 01期

关键词：

DIRECTED ORTHO BORYLATION; CROSS-COUPLING REACTIONS; ARYL HALIDES; ROOM-TEMPERATURE; FUNCTIONALIZED ARENES; AROMATIC BORYLATION; DIBORON REAGENTS; BOND FORMATION; PALLADIUM; PINACOLBORANE;

D O I：

10.1021/ja2097095

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of a Pd-catalyzed oxidative ortho-C-H borylation with N-arylbenzamides is reported. A modified dibenzylideneacetone (dba) ligand, a weak base, and a strong oxidant are critical for obtaining good yields. The reaction is tolerant of electron-deficient and electron-rich benzamides derived from readily available benzoic acids. The borylated products can be converted to various synthons via diverse transformations.

引用

页码：134 / 137

页数：4

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