Catalytic enantioselective alkyl and aryl addition to aldehydes and ketones with organozinc reagents derived from alkyl Grignard reagents or arylboronic acids

被引：52

作者：

Hatano, Manabu ^{[1
]}

Gouzu, Riku ^{[2
]}

Mizuno, Tomokazu ^{[1
]}

Abe, Hitoshi ^{[2
]}

Yamada, Toshihide ^{[2
]}

Ishihara, Kazuaki ^{[1
,3
]}

机构：

[1] Nagoya Univ, Grad Sch Engn, Chikusa Ku, Nagoya, Aichi 4648603, Japan

[2] Sekisui Med Co Ltd, Hachimantai, Iwate 0287305, Japan

[3] Japan Sci & Technol Agcy JST, CREST, Chikusa Ku, Nagoya, Aichi 4648603, Japan

来源：

CATALYSIS SCIENCE & TECHNOLOGY | 2011年 / 1卷 / 07期

关键词：

CHIRAL SECONDARY ALCOHOLS; GREEN CHEMISTRY APPROACH; ASYMMETRIC-SYNTHESIS; ALLYLIC ALCOHOLS; DIORGANOZINC COMPOUNDS; DIALKYLZINC ADDITION; ENANTIOMERIC EXCESS; RECENT PROGRESS; PHENYL TRANSFER; BASE CATALYSTS;

D O I：

10.1039/c1cy00108f

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A highly practical, catalytic enantioselective alkyl and aryl addition to aldehydes and ketones with organozinc reagents, which were prepared in situ from commercially available Grignard reagents or arylboronic acids, was developed. A chiral phosphoramide ligand was essential for promoting the addition reactions in high yields with high enantioselectivities.

引用

页码：1149 / 1158

页数：10

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