Quantum-Dot-Based FRET Detection of Histone Acetyltransferase Activity

被引：58
|
作者：
Ghadiali, James E.
Lowe, Stuart B.
Stevens, Molly M. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Dept Mat, Dept Bioengn, London SW7 2AZ, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 15期
基金：
英国工程与自然科学研究理事会;
关键词：
biosensors; enzymes; epigenetics; FRET; nanoparticles; RESONANCE ENERGY-TRANSFER; MODIFYING ENZYMES; ANACARDIC ACID; ASSAY; EPIGENETICS; INHIBITORS; DISEASE; KINASE; P300; ASSEMBLIES;
D O I：
10.1002/anie.201008263
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Straightforward and label-free: A simple method for the detection of histone-modifying enzymes is based on quantum dot (QD) Förster resonance energy transfer (FRET) donors. Histone acetyltransferase activity can be measured via the enzyme-dependent assembly of a quantum dot/peptide immunocomplex (see picture; His=histidine), which can be conducted in a homogeneous reaction without the need for complicated surface derivatization procedures. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：3417 / 3420
页数：4
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