Limited Impact of Fc-dependent Functions on the Efficacy of the Anti-HIV-1 Broadly Neutralizing Antibody PGT121 in Macaques

被引：0
|
作者：
Parsons, Matthew [1 ]
Lee, Wen Shi [1 ]
Kristensen, Anne [1 ]
Amarasena, Thakshila [1 ]
Khoury, Georges [1 ]
Davenport, Miles [2 ]
Kent, Stephen [1 ]
机构：
[1] Univ Melbourne, Melbourne, Vic, Australia
[2] Kirby Inst, Kensington, NSW, Australia
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2018年 / 34卷
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
P20.03
引用
收藏
页码：339 / 339
页数：1
相关论文
共 44 条
  • [1] Fc-dependent functions are redundant to efficacy of anti-HIV antibody PGT121 in macaques
    Parsons, Matthew S.
    Lee, Wen Shi
    Kristensen, Anne B.
    Amarasena, Thakshila
    Khoury, Georges
    Wheatley, Adam K.
    Reynaldi, Arnold
    Wines, Bruce D.
    Hogarth, P. Mark
    Davenport, Miles P.
    Kent, Stephen J.
    JOURNAL OF CLINICAL INVESTIGATION, 2019, 129 (01): : 182 - 191
  • [2] Protective efficacy of the anti-HIV broadly neutralizing antibody PGT121 in the context of semen exposure
    Parsons, Matthew S.
    Kristensen, Anne B.
    Selva, Kevin J.
    Lee, Wen Shi
    Amarasena, Thakshila
    Esterbauer, Robyn
    Wheatley, Adam K.
    Bavinton, Benjamin R.
    Kelleher, Anthony D.
    Grulich, Andrew E.
    Khoury, Georges
    Juno, Jennifer A.
    Kent, Stephen J.
    EBIOMEDICINE, 2021, 70
  • [3] Modeling resistance to the broadly neutralizing antibody PGT121 in people living with HIV-1
    Cassidy, Tyler
    Stephenson, Kathryn E.
    Barouch, Dan H.
    Perelson, Alan S.
    PLOS COMPUTATIONAL BIOLOGY, 2024, 20 (03)
  • [4] Anti-Drug Antibodies in Pigtailed Macaques Receiving HIV Broadly Neutralising Antibody PGT121
    Lee, Wen Shi
    Reynaldi, Arnold
    Amarasena, Thakshila
    Davenport, Miles P.
    Parsons, Matthew S.
    Kent, Stephen J.
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [5] Griffithsin Retains Anti-HIV-1 Potency with Changes in gp120 Glycosylation and Complements Broadly Neutralizing Antibodies PGT121 and PGT126
    Fischer, Kathryn
    Nguyen, Kimberly
    LiWang, Patricia J.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020, 64 (01)
  • [6] Protection against SHIV Challenge by Subcutaneous Administration of the Plant-Derived PGT121 Broadly Neutralizing Antibody in Macaques
    Rosenberg, Yvonne J.
    Montefiori, David C.
    LaBranche, Celia C.
    Lewis, Mark G.
    Sack, Markus
    Lees, Jonathan P.
    Jiang, Xiaoming
    PLOS ONE, 2016, 11 (03):
  • [7] Importance of Fc-mediated functions of anti-HIV-1 broadly neutralizing antibodies
    Matthew S. Parsons
    Amy W. Chung
    Stephen J. Kent
    Retrovirology, 15
  • [8] Importance of Fc-mediated functions of anti-HIV-1 broadly neutralizing antibodies
    Parsons, Matthew S.
    Chung, Amy W.
    Kent, Stephen J.
    RETROVIROLOGY, 2018, 15
  • [9] Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity
    Bournazos, Stylianos
    Klein, Florian
    Pietzsch, John
    Seaman, Michael S.
    Nussenzweig, Michel C.
    Ravetch, Jeffrey V.
    CELL, 2014, 158 (06) : 1243 - 1253
  • [10] Partial efficacy of broadly neutralizing antibody PGT121 against cell-associated simian-human immunodeficiency virus (SHIV) infection
    Parsons, M.
    Lloyd, S.
    Center, R.
    Amarasena, T.
    Swiderek, K.
    Kent, S.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 629 - 629
12345