Exposure to food additive mixtures in 106,000 French adults from the NutriNet-Sante cohort

被引:50
|
作者
Chazelas, Eloi [1 ,2 ]
Druesne-Pecollo, Nathalie [1 ,2 ]
Esseddik, Younes [1 ]
de Edelenyi, Fabien Szabo [1 ]
Agaesse, Cedric [1 ]
De Sa, Alexandre [1 ]
Lutchia, Rebecca [1 ]
Rebouillat, Pauline [1 ,2 ]
Srour, Bernard [1 ,2 ]
Debras, Charlotte [1 ,2 ]
Wendeu-Foyet, Gaelle [1 ,2 ]
Huybrechts, Inge [2 ,3 ]
Pierre, Fabrice [2 ,4 ]
Coumoul, Xavier [2 ,5 ,7 ]
Julia, Chantal [1 ,2 ,6 ]
Kesse-Guyot, Emmanuelle [1 ,2 ]
Alles, Benjamin [1 ]
Galan, Pilar [1 ,2 ]
Hercberg, Serge [1 ,2 ,6 ]
Deschasaux-Tanguy, Melanie [1 ,2 ]
Touvier, Mathilde [1 ,2 ]
机构
[1] Univ Paris CRESS, Sorbonne Paris Nord Univ, INSERM,Inrae,Nutr Epidemiol Res Team EREN, Cnam,SMBH,Epidemiol & Stat Res Ctr,U1153,U1125, F-93017 Bobigny, France
[2] French Network Nutr & Canc Res, NACRe Network, Jouy En Josas, France
[3] WHO, Int Agcy Res Canc, Lyon, France
[4] Univ Toulouse, INRAE, Toxalim Res Ctr Food Toxicol, UPS,ENVT,INP Purpan, Toulouse, France
[5] INSERM, Toxicol Environm Cibles Therapeut Signalisat Cell, T3S, UMR S1124, Paris, France
[6] Avicenne Hosp, AP HP, Publ Hlth Dept, Bobigny, France
[7] Univ Paris, Paris, France
基金
欧洲研究理事会;
关键词
ULTRA-PROCESSED FOODS; DIETARY EXPOSURE; CANCER RISK; LIFE-SPAN; EMULSIFIERS; SULFITES; NITRITE; NITRATE; ASPARTAME; CONSUMPTION;
D O I
10.1038/s41598-021-98496-6
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Food additives (e.g. artificial sweeteners, emulsifiers, dyes, etc.) are ingested by billions of individuals daily. Some concerning results, mainly derived from animal and/or cell-based experimental studies, have recently emerged suggesting potential detrimental effects of several widely consumed additives. Profiles of additive exposure as well as the potential long-term impact of multiple exposure on human health are poorly documented. This work aimed to estimate the usual intake of food additives among participants of the French NutriNet-Sante cohort and to identify and describe profiles of exposure (single substances and mixtures). Overall, 106,489 adults from the French NutriNet-Sante cohort study (2009-ongoing) were included. Consumption of 90 main food additives was evaluated using repeated 24 h dietary records including information on brands of commercial products. Qualitative information (as presence/absence) of each additive in food products was determined using 3 large-scale composition databases (OQALI, Open Food Facts, GNPD), accounting for the date of consumption of the product. Quantitative ingested doses were estimated using a combination of laboratory assays on food matrixes (n = 2677) and data from EFSA and JECFA. Exposure was estimated in mg per kg of body weight per day. Profiles of exposure to food additive mixtures were extracted using Non-negative Matrix Factorization (NMF) followed by k-means clustering as well as Graphical Lasso. Sociodemographic and dietary comparison of clusters of participants was performed by Chi-square tests or linear regressions. Data were weighted according to the national census. Forty-eight additives were consumed by more than 10% of the participants, with modified starches and citric acid consumed by more than 90%. The top 50 also included several food additives for which potential adverse health effects have been suggested by recent experimental studies: lecithins (86.6% consumers), mono- and diglycerides of fatty acids (78.1%), carrageenan (77.5%), sodium nitrite (73.9%), di-, tri- and polyphosphates (70.1%), potassium sorbate (65.8%), potassium metabisulphite (44.8%), acesulfame K (34.0%), cochineal (33.9%), potassium nitrate (31.6%), sulfite ammonia caramel (28.8%), bixin (19.5%), monosodium glutamate (15.1%) and sucralose (13.5%). We identified and described five clusters of participants more specifically exposed to five distinct additive mixtures and one additional cluster gathering participants with overall low additive exposure. Food additives, including several for which health concerns are currently debated, were widely consumed in this population-based study. Furthermore, main mixtures of additives were identified. Their health impact and potential cocktail effects should be explored in future epidemiological and experimental studies.
引用
收藏
页数:21
相关论文
共 50 条
  • [1] Exposure to food additive mixtures in 106,000 French adults from the NutriNet-Santé cohort
    Eloi Chazelas
    Nathalie Druesne-Pecollo
    Younes Esseddik
    Fabien Szabo de Edelenyi
    Cédric Agaesse
    Alexandre De Sa
    Rebecca Lutchia
    Pauline Rebouillat
    Bernard Srour
    Charlotte Debras
    Gaëlle Wendeu-Foyet
    Inge Huybrechts
    Fabrice Pierre
    Xavier Coumoul
    Chantal Julia
    Emmanuelle Kesse-Guyot
    Benjamin Allès
    Pilar Galan
    Serge Hercberg
    Mélanie Deschasaux-Tanguy
    Mathilde Touvier
    Scientific Reports, 11
  • [2] Exposure to food additive mixtures and type 2 diabetes risk in the NutriNet-Sante cohort
    de la Garanderie, M. Payen
    Deschamp, N.
    Hasenboehler, A.
    Javaux, G.
    de Edelenyi, F. Szabo
    Agaesse, C.
    De Sa, A.
    Deschasaux-Tanguy, M.
    Srour, B.
    Touvier, M.
    EUROPEAN JOURNAL OF PUBLIC HEALTH, 2024, 34
  • [3] Food additive emulsifiers and cancer risk: results from the French prospective NutriNet-Sante cohort
    Sellem, L.
    Srour, B.
    Chazelas, E.
    Debras, C.
    Chassaing, B.
    Huybrechts, I.
    Pierre, F.
    Coumoul, X.
    Deschasaux-Tanguy, M.
    Touvier, M.
    EUROPEAN JOURNAL OF PUBLIC HEALTH, 2022, 32
  • [4] Food additive emulsifiers and cancer risk: Results from the French prospective NutriNet-Sante cohort
    Sellem, Laury
    Srour, Bernard
    Javaux, Guillaume
    Chazelas, Eloi
    Chassaing, Benoit
    Viennois, Emilie
    Debras, Charlotte
    Druesne-Pecollo, Nathalie
    Esseddik, Younes
    de Edelenyi, Fabien Szabo
    Arnault, Nathalie
    Agaesse, Cedric
    De Sa, Alexandre
    Lutchia, Rebecca
    Huybrechts, Inge
    Scalbert, Augustin
    Pierre, Fabrice
    Coumoul, Xavier
    Julia, Chantal
    Kesse-Guyot, Emmanuelle
    Alles, Benjamin
    Galan, Pilar
    Hercberg, Serge
    Deschasaux-Tanguy, Melanie
    Touvier, Mathilde
    PLOS MEDICINE, 2024, 21 (02)
  • [5] Food additive emulsifiers and cancer risk: results from the French prospective NutriNet-Sante cohort
    Sellem, Laury
    Srour, Bernard
    Chazelas, Eloi
    Debras, Charlotte
    Chassaing, Benoit
    Huybrechts, Inge
    Pierre, Fabrice
    Coumoul, Xavier
    Deschasaux-Tanguy, Melanie
    Touvier, Mathilde
    ANNALS OF NUTRITION AND METABOLISM, 2023, 79 : 392 - 392
  • [6] Contribution of Organic Food to the Diet in a Large Sample of French Adults (the NutriNet-Sante Cohort Study)
    Baudry, Julia
    Mejean, Caroline
    Alles, Benjamin
    Peneau, Sandrine
    Touvier, Mathilde
    Hercberg, Serge
    Lairon, Denis
    Galan, Pilar
    Kesse-Guyot, Emmanuelle
    NUTRIENTS, 2015, 7 (10) : 8615 - 8632
  • [7] Food additive monosodium glutamate and risk of cardiovascular diseases - NutriNet-Sante cohort
    Hasenbohler, A.
    Javaux, G.
    de la Garanderie, M. Payen
    de Edelenyi, F. Szabo
    Agaesse, C.
    De Sa, A.
    Deschasaux-Tanguy, M.
    Fezeu, L.
    Srour, B.
    Touvier, M.
    EUROPEAN JOURNAL OF PUBLIC HEALTH, 2024, 34
  • [8] FODMAP Consumption by Adults from the French Population-Based NutriNet-Sante Cohort
    Schneider, Elodie
    Sabate, Jean-Marc
    Bouchoucha, Michel
    Debras, Charlotte
    Touvier, Mathilde
    Hercberg, Serge
    Benamouzig, Robert
    Buscail, Camille
    Julia, Chantal
    JOURNAL OF NUTRITION, 2021, 151 (10): : 3180 - 3186
  • [9] Dietary pesticide exposure profiles in the NutriNet-Sante cohort
    Rebouillat, P.
    Vidal, R.
    Cravedi, J-P
    Debrauwer, L.
    Gamet-Payrastre, L.
    Touvier, M.
    Hercberg, S.
    Lairon, D.
    Baudry, J.
    Kesse-Guyot, E.
    EUROPEAN JOURNAL OF PUBLIC HEALTH, 2019, 29
  • [10] Profiles of Organic Food Consumers in a Large Sample of French Adults: Results from the Nutrinet-Sante Cohort Study
    Kesse-Guyot, Emmanuelle
    Peneau, Sandrine
    Mejean, Caroline
    de Edelenyi, Fabien Szabo
    Galan, Pilar
    Hercberg, Serge
    Lairon, Denis
    PLOS ONE, 2013, 8 (10):