3-pentyl (Pen) group as a new base-resistant side chain protecting group for tyrosine

被引：11
|
作者：
Bódi, J [1 ]
Nishiuchi, Y [1 ]
Nishio, H [1 ]
Inui, T [1 ]
Kimura, T [1 ]
机构：
[1] Peptide Inst Inc, Prot Res Fdn, Minoh, Osaka 5628686, Japan
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 39期
关键词：
amino acids and derivatives; protecting groups; cleavage reaction; migration;
D O I：
10.1016/S0040-4039(98)01511-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The 3-pentyl (Pen) group is a new base-resistant protecting group for tyrosine. It is sufficiently stable in 50% TFA/DCM and completely stable towards 20% piperidine/DMF but is readily cleavable by the standard HF procedure without the formation of any significant amount of alkyltyrosine rearrangement product. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7117 / 7120
页数：4
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