Impact of high MIC of fluconazole on outcomes of Candida glabrata bloodstream infection: a retrospective multicenter cohort study

被引：10

作者：

Ko, Jae-Hoon ^{[1
,9
]}

Peck, Kyong Ran ^{[1
]}

Jung, Dong Sik ^{[2
]}

Lee, Ji Yeon ^{[3
]}

Kim, Hyun Ah ^{[3
]}

Ryu, Seong Yeol ^{[3
]}

Jung, Sook-In ^{[4
]}

Joo, Eun-Jeong ^{[5
]}

Cheon, Shinhye ^{[6
]}

Kim, Yeon-Sook ^{[6
]}

Kim, Shin-Woo ^{[7
]}

Cho, Sun Young ^{[1
]}

Ha, Young Eun ^{[1
]}

Kang, Cheol-In ^{[1
]}

Chung, Doo Ryeon ^{[1
]}

Lee, Nam Yong ^{[8
]}

Song, Jae-Hoon ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Div Infect Dis, Dept Med, Seoul, South Korea

[2] Dong A Univ, Div Infect Dis, Coll Med, Busan, South Korea

[3] Keimyung Univ, Div Infect Dis, Dongsan Med Ctr, Daegu, South Korea

[4] Chonnam Natl Univ Hosp, Div Infect Dis, Gwangju, South Korea

[5] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Internal Med,Div Infect Dis, Seoul, South Korea

[6] Chungnam Natl Univ, Sch Med, Div Infect Dis, Daejeon, South Korea

[7] Kyungpook Natl Univ, Sch Med, Div Infect Dis, Daegu, South Korea

[8] Sungkyunkwan Univ, Sch Med, Dept Lab Med, Samsung Med Ctr, Seoul, South Korea

[9] Armed Forces Capital Hosp, Div Infect Dis, Dept Internal Med, Seongnam, South Korea

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2018年 / 92卷 / 02期

关键词：

Candida glabrata; fluconazole; echinocandin; amphotericin; minimum inhibitory concentration; CLINICAL-PRACTICE GUIDELINE; ANTIFUNGAL SUSCEPTIBILITY; DISEASES SOCIETY; AMPHOTERICIN-B; EPIDEMIOLOGY; UPDATE; MANAGEMENT;

D O I：

10.1016/j.diagmicrobio.2018.05.001

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

To evaluate the impacts of fluconazole minimum inhibitory concentration (MIC) according to primary antifungal agents on Candida glabrata bloodstream infection (BSI), a multicenter retrospective cohort study was conducted in Korea, concerning the time period from January 2010 to February 2016. A total of 197 adult patients with C. glabrata BSI were included in the study, and neutropenia (P = 0.026), APACHE II score (P = 0.004), and fluconazole resistance (HR 3.960, 95% CI 1.395-11.246, P = 0.010) were associated with 30-day mortality in multivariate analysis. In subgroup analysis, fluconazole MIC = 32 mu g/mL in the azole-treated group (HR 6.691, 95% CI 1.569-28.542, P = 0.010) and fluconazole MIC = 64 mu g/mL in the non-azole-treated group (HR 3.337, 95% CI 1.183-9.411, P = 0.023) showed the highest hazard ratio (HR) for 30-day mortality. Increased fluconazole MIC was associated with poor outcome both in azole- and non-azole-treated patients with C. glabrata BSI. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：127 / 132

页数：6

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