Palladium-catalyzed oxidative C-H activation/annulation of N-alkylanilines with bromoalkynes: access to functionalized 3-bromoindoles

被引：5

作者：

Fang, Songjia ^{[1
]}

Chen, Wenhao ^{[1
]}

Jiang, Huanfeng ^{[1
]}

Ma, Ruize ^{[1
]}

Wu, Wanqing ^{[1
]}

机构：

[1] South China Univ Technol, Sch Chem & Chem Engn, State Key Lab Luminescent Mat & Devices, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 69期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; TANDEM REACTION; INDOLES; ACTIVATION; EFFICIENT; ACIDS; ALKYNYLATION; BROMINATION; CYCLIZATION; ANNULATION;

D O I：

10.1039/d2cc03298h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A straightforward approach to the synthesis of 3-bromoindoles via palladium-catalyzed oxidative C-H activation/annulation of N-alkylanilines with bromoalkynes has been described. This protocol features high atom economy, excellent chemo- and regioselectivities, and good functional group tolerance. Moreover, the resultant 3-bromoindoles can be transformed to various functionalized indole derivatives, which demonstrates the practicability of this method in organic synthesis.

引用

页码：9666 / 9669

页数：4

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