Further new cembrane Diterpenes from the hainan soft coral Sarcophyton latum

被引：8
|
作者：
Yan Xiao-Hong [1 ]
Feng Lin-Yin [1 ]
Guo Yue-Wei [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2008年 / 26卷 / 01期
关键词：
soft coral; Sarcophyton latum; chemical constituent; cembrane diterpene;
D O I：
10.1002/cjoc.200890011
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two new cembranoid diterpenes, diepoxysarcophytonene (1) and sarconphytonol (2), were isolated from the Hainan soft coral Sarcophyton latum. Their structures including relative stereochemistry were established by 1D and 2D NMR spectroscopic techniques. Compound I showed weak inhibitory activity against COX-2 in vitro at the concentration of 10(-5) mu mol.L-1 with the inhibitory rate of 55%.
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收藏
页码：150 / 152
页数：3
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