ATP in endolymph enhances electrically-evoked oto-acoustic emissions from the guinea pig cochlea

被引：18

作者：

Kirk, DL ^{[1
]}

Yates, GK ^{[1
]}

机构：

[1] Univ Western Australia, Dept Physiol, Nedlands, WA 6097, Australia

来源：

NEUROSCIENCE LETTERS | 1998年 / 250卷 / 03期

基金：

英国医学研究理事会;

关键词：

adenosine triphosphate; hair cell; cochlea; electromotility; oto-acoustic emission; iontophoresis;

D O I：

10.1016/S0304-3940(98)00460-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

ATP was iontophoresed into the scala media of the guinea pig cochlea. A reversible increase in the amplitude of electrically-evoked oto-acoustic emissions (EEOAEs), and reductions in the endocochlear potential (EP) and the cochlear microphonic (CM) were observed. These effects were consistent with an action of ATP on P-2x receptors on outer hair cells (OHC). The results confirm that endogenous endolymphatic ATP, acting via P-2x receptors on OHCs, may serve a regulatory function in the cochlea. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：149 / 152

页数：4

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