Intensity-modulated radiotherapy of head and neck cancers. Dose constraint for spinal cord and brachial plexus

被引：10
|
作者：
Boisselier, P. [1 ]
Racadot, S. [2 ]
Thariat, J. [3 ]
Graff, P. [4 ]
Pointreau, Y. [5 ]
机构：
[1] Inst Canc Montpellier, Dept Radiotherapie, 208 Ave Apothicaires, F-34298 Montpellier, France
[2] Ctr Leon Berard, Dept Radiotherapie, 28 Rue Laennec, F-69008 Lyon, France
[3] Ctr Antoine Lacassagne, Dept Radiotherapie, 33 Ave Valombrose, F-06189 Nice, France
[4] Inst Univ Canc Toulouse Oncopole, Dept Radiotherapie, 1 Ave Irene Joliot Curie, F-31059 Toulouse, France
[5] Ctr Jean Bernard, Inst Interreg Cancerol, Clin Victor Hugo, 9 Rue Beauverger, F-72000 Le Mans, France
来源：
CANCER RADIOTHERAPIE | 2016年 / 20卷 / 6-7期
关键词：
Head and neck cancer; Intensity-modulated radiotherapy; Organ at risk; Spinal cord; Brachial plexus; RADIATION-INDUCED MYELOPATHY; CENTRAL-NERVOUS-SYSTEM; RANDOMIZED PHASE-II; LHERMITTES SIGN; NORMAL TISSUE; INDUCED NEUROTOXICITY; HYPERBARIC-OXYGEN; THERAPY; TOLERANCE; IMRT;
D O I：
10.1016/j.canrad.2016.08.124
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Given the ballistic opportunities it offers, intensity-modulated radiotherapy has emerged as the gold standard treatment for head and neck cancers. Protection of organs at risk is one of the objectives of optimization during the planning process. The compliance of dose constraints to the nervous system must be prioritized over all others. To avoid complications, it is recommended to respect a maximum dose of 50 Gy to the spinal cord, and 60 Gy to the brachial plexus using conventional fractionation of 2 Gy per fraction. These constraints can be adapted depending on the clinical situation; they will probably be refocused by the follow-up of the IMRT studies. (C). 2016 Published by Elsevier Masson SAS on behalf of Societe francaise de radiotherapie oncologique (SFRO).
引用
收藏
页码：459 / 466
页数：8
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