Relationship between strain elastography and histopathological parameters in breast cancer

Purpose: This study aimed to evaluate the relationship between strain elastography and immunohistochemical markers, the histologic grade, and molecular subtyping in invasive breast cancer. Materials and Methods: The relationships between the elastography index values and progesterone receptor, estrogen receptor, human epidermal growth factor receptor 2, Ki-67, the histologic grade, and molecular subtype in 171 patients who had not received neoadjuvant treatment and underwent breast-conserving surgery were evaluated. Strain elastosonography were used to evaluate elastography index. Results: The mean patient age was 46.871 +/- 11.949 years. There were 135, 129, and 90 estrogen receptor-positive, progesterone receptor-positive, and human epidermal growth factor receptor 2-positive patients, respectively. Forty-seven patients had the worst histological grade. Based on molecular subtyping, human epidermal growth factor receptor 2-positive, luminal A, luminal B, and triple -negative classifications were made for 25 (14.5%), 29 (17.0%), 109 (63.7%), and 8 (4.7%) cases, respectively. There was no statistically significant correlation between the elastography index values and estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67, histologic grade, or molecular subtype among these breast resection cases. Conclusion: The elastography index value was insufficient to predict the specified histopathological parameters.