Anti-citrullinated protein antibodies (ACPA) in early rheumatoid arthritis

被引：27

作者：

Suwannalai, Parawee ^{[1
,2
]}

Trouw, Leendert A. ^{[1
]}

Toes, Rene E. M. ^{[1
]}

Huizinga, Tom W. J. ^{[1
]}

机构：

[1] Leiden Univ, Dept Rheumatol, Med Ctr, NL-2300 RC Leiden, Netherlands

[2] Mahidol Univ, Ramathibodi Hosp, Fac Med, Allergy Immunol & Rheumatol Div, Bangkok 10400, Thailand

来源：

MODERN RHEUMATOLOGY | 2012年 / 22卷 / 01期

关键词：

Anti-citrullinated protein antibodies; ACPA; Early RA; Pre-RA; Antibody maturation; HLA-DRB1 SHARED EPITOPE; PLACEBO-CONTROLLED TRIAL; PEPTIDE ANTIBODIES; UNDIFFERENTIATED ARTHRITIS; ANTIPERINUCLEAR FACTOR; PROSPECTIVE COHORT; DOUBLE-BLIND; RADIOGRAPHIC PROGRESSION; DIAGNOSTIC-VALUE; JOINT DAMAGE;

D O I：

10.1007/s10165-011-0486-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoantibodies with the highest specificity for rheumatoid arthritis (RA) are the antibodies directed to citrulline-containing epitopes, so-called anti-citrullinated peptide/protein antibodies (ACPA). During the past decade it became clear that the presence of these antibodies was highly predictive of and specific for RA, and illustrating the importance of ACPA. Therefore, the presence of these antibodies is one of the new American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) 2010 criteria for RA. Apart from the presence of these antibodies, the composition of this antibody response matures during RA development. This review summarizes the current knowledge of the characteristics of ACPA in RA development.

引用

下载

页码：15 / 20

页数：6

共 50 条

[1] ACPA [ANTI-CITRULLINATED PROTEIN ANTIBODIES) AND RHEUMATOID ARTHRITIS
Toes, Rene E. M.
van der Woude, Diane
ACTA REUMATOLOGICA PORTUGUESA, 2011, 36 (03): : 205 - 207
[2] The role of anti-citrullinated protein antibodies (ACPA) in the pathogenesis of rheumatoid arthritis
Kurowska, Weronika
Kuca-Warnawin, Ewa H.
Radzikowska, Anna
Maslinski, Wlodzimierz
CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY, 2017, 42 (04) : 390 - 398
[3] Anti-citrullinated protein/peptide antibodies (ACPA) in rheumatoid arthritis: Specificity and relation with rheumatoid factor
Vander Cruyssen, B
Peene, I
Cantaert, T
Hoffman, IEA
De Rycke, L
Veys, EM
De Keyser, F
AUTOIMMUNITY REVIEWS, 2005, 4 (07) : 468 - 474
[4] Prognostic value of anti-citrullinated protein antibodies in early rheumatoid arthritis
Finet, Florian
Descamps, Olivier
Focant, Isabelle
ACTA CLINICA BELGICA, 2017, 72 : 6 - 6
[5] Autoantibodies in rheumatoid arthritis:: Anti-citrullinated protein antibodies (ACPA) and type II collagen specificities
Mahdi, H.
Snir, O.
Holmdahl, R.
Venables, P.
Klareskog, L.
Widhe, M.
Malmstroem, V.
ANNALS OF THE RHEUMATIC DISEASES, 2008, 67 : A7 - A8
[6] Specificity of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis
Trier, Nicole H.
Holm, Bettina E.
Hansen, Paul R.
Slot, Ole
Locht, Henning
Houen, Gunnar
ANTIBODIES, 2019, 8 (02)
[7] Anti-citrullinated protein antibodies as biomarkers in rheumatoid arthritis
Trier, Nicole Hartwig
Houen, Gunnar
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023, : 895 - 911
[8] Anti-citrullinated protein antibodies as biomarkers in rheumatoid arthritis
Trier, Nicole Hartwig
Houen, Gunnar
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023,
[9] IN RHEUMATOID ARTHRITIS, SMOKING IS NOT ASSOCIATED WITH ANTI-CITRULLINATED PROTEIN ANTIBODIES (ACPA) PER SE, BUT WITH THE CONCURRENT PRESENCE OF RHEUMATOID FACTOR, ACPA AND ANTI-CARBAMYLATED PROTEIN ANTIBODIES
van Wesemael, T. J.
Muhammad, A.
Symmons, D. P.
MacGregor, A. J.
Barton, A.
Trouw, L. A.
Huizinga, T. W. J.
Toes, R. E. M.
Verstappen, S. M. M.
van der Woude, D.
ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 : 206 - 207
[10] Pathogenesis and Prevalence of Anti-Citrullinated Protein Antibodies (ACPA) in Unaffected Siblings of ACPA-Positive Rheumatoid Arthritis Patients
Barra, Lillian
Scinocca, Mathias
Wilson, Elizabeth
Summers, Kelly
Cairns, Ewa
Bell, David
JOURNAL OF RHEUMATOLOGY, 2011, 38 (06) : 1140 - 1140

← 1 2 3 4 5 →