Anidulafungin and Micafungin Concentrations in Cerebrospinal Fluid and in Cerebral Cortex

Anidulafungin and micafungin were quantified in cerebrospinal fluid (CSF) of critically ill adults and in cerebral cortex of deceased patients. In CSF, anidulafungin levels (<0.01 to 0.66 mu g/ml) and micafungin levels (<0.01 to 0.16 mu g/ml) were lower than those in plasma concentrations (0.77 to 5.07 and 1.21 to 8.70 mu g/ml, respectively) drawn simultaneously. In cerebral cortex, anidulafungin and micafungin levels were 0.21 to 2.34 and 0.18 to 2.88 mu g/g, respectively. Thus, MIC values of several pathogenic Candida strains exceed concentrations in CSF and in brain.