Increased histone deacetylase activity in peripheral blood mononuclear cells of patients with schizophrenia

被引：4

作者：

Pang, Bo ^{[1
]}

Wang, Jingyi ^{[1
]}

Zhang, Wenbin ^{[1
]}

Gao, Yuan ^{[1
]}

Zhang, Jinrong ^{[1
]}

Su, Yingying ^{[1
]}

Kou, Changgui ^{[1
]}

机构：

[1] Jilin Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Changchun 130021, Jilin, Peoples R China

来源：

PSYCHIATRY RESEARCH | 2016年 / 245卷

关键词：

Schizophrenia; Histone deacetylases; Human peripheral blood mononuclear cell; GENE PROMOTERS; VALPROIC ACID; POPULATION; ASSOCIATION; RISPERIDONE; EXPRESSION; REPRESSION; OLANZAPINE; INHIBITORS; HDAC2;

D O I：

10.1016/j.psychres.2016.07.060

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

This study investigates the association between histone deacetylase (HDAC) activity in human peripheral blood mononuclear cells (PBMCs) and schizophrenia. Data were derived from a case-control association study of 19 unrelated adult patients with schizophrenia and 21 matched healthy controls. HDAC activity was measured with a HDAC activity colorimetric assay kit. Our findings suggest that HDAC activity in PBMCs is higher in patients with schizophrenia than in healthy people. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：105 / 107

页数：3

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