Challenges to Developing a Rotavirus Vaccine

被引：11

作者：

Offit, Paul A. ^{[1
]}

机构：

[1] Univ Penn, Perelman Sch Med, Childrens Hosp Philadelphia, Div Infect Dis, Philadelphia, PA 19104 USA

来源：

VIRAL IMMUNOLOGY | 2018年 / 31卷 / 02期

关键词：

rotavirus; vaccine development; gastroenteritis; DIARRHEAL DISEASE; YOUNG-CHILDREN; GLOBAL PROBLEM; MURINE MODEL; WC3; VACCINE; PROTECTION; INFANTS; EFFICACY; GASTROENTERITIS; INFECTION;

D O I：

10.1089/vim.2017.0121

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rotavirus is the most important cause of gastroenteritis worldwide. In developing countries, the virus is a major cause of death in infants and young children. In the United States, before the licensure of vaccines, rotavirus infections accounted for approximate to 2.7 million cases of gastroenteritis annually. Here are described the history and challenges surrounding the development of a rotavirus vaccine.

引用

页码：104 / 108

页数：5

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