Spirometric and flow-volume curve analysis in rats, and optimal parameters for estimating obstructive impairment

被引：2

作者：

Kondo, Tetsuri ^{[1
]}

Tanigaki, Toshimori ^{[2
]}

Tsuji, Chizuko ^{[3
]}

Watanabe, Hidehiro ^{[1
]}

机构：

[1] Tokai Univ Hachioji Hosp, Dept Resp Med, Tokyo 1920032, Japan

[2] Tokai Univ, Dept Clin Hlth Sci, Sch Med, Kanagawa 2591193, Japan

[3] Tokai Univ, Dept Physiol, Sch Med, Kanagawa 2591193, Japan

来源：

JOURNAL OF PHYSIOLOGICAL SCIENCES | 2010年 / 60卷 / 05期

基金：

日本学术振兴会;

关键词：

Flow limitation; Lung function test; Small animals; EXPIRATORY FLOW; LIMITATION; ACETYLCHOLINE; METHACHOLINE; MECHANICS;

D O I：

10.1007/s12576-010-0097-8

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

We obtained flow-volume (F-V) curves in anesthetized rats by applying positive pressure on the body surface. To obtain the best curve, tracheal intubation with either a 12 or 13 gauge catheter and a surface pressure greater than 56 cmH(2)O was necessary. Peak expiratory flow rate (PEFR) and forced vital capacity (FVC) were shown to be optimal parameters for estimation of bronchoconstriction induced by methacholine inhalation while FEV0.05 (forced expiratory volume at 0.05 s) and FEV0.10 were of limited usefulness for this purpose. The descending segment of the F-V curve consisted of two or three phases, with later phases shortened during bronchoconstriction. In conclusion, PEFR and FVC are optimal parameters for estimation of bronchoconstriction in rats. The decreases in PEFR and FVC may reflect constriction in large and smaller airways, respectively.

引用

页码：309 / 316

页数：8

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