Preparation of graded zirconia-hydroxyapatite composite bioceramic and its immunocompatibility in vitro

被引：9

作者：

Quan, Renfu

Yang, Disheng ^{[1
]}

Miao, Xudong

Wu, Xiaochun

Wang, Hongbin

Li, Wei

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Dept Orthopaed, Hangzhou 310009, Peoples R China

[2] Shanghai Univ, Sch Mat Sci & Engn, Shanghai 200072, Peoples R China

[3] Xiaoshan Tradit Chinese Med Hosp, Dept Orthopaed, Hangzhou 311201, Peoples R China

来源：

JOURNAL OF BIOMATERIALS APPLICATIONS | 2007年 / 22卷 / 02期

关键词：

zirconia; hydroxyapatite; graded composite material; biocompatibility; immunocompatibility;

D O I：

10.1177/0885328206071454

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

To obtain immunocompatibility, graded zirconia-hydroxyapatite (ZrO2-HA) composite bioceramic and simplex ZrO2-HA composite bioceramic are prepared. Peripheral blood mononuclear cells (PBMCs) harvested from healthy individuals are cultured with the two ceramic extracts to assess their effect on the transformation of lymphocytes, apoptotic ratio, CD69 expression, and expression of cytokine of TNF alpha and IL-6, with or without phytohemoagglutinin (PHA)-stimulated cells. Ceramic extracts did not activate the resting lymphocytes, whereas the response of the PHA-stimulated cells was significantly modified. The PBMCs activated by graded ZrO2-HA composite bioceramic is noticeably smaller than that by simplex ZrO2-HA composite bioceramic; these results, however can only be seen under the amplified effect of PHA-stimulation.

引用

页码：123 / 144

页数：22

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