Hippocampal contributions to social and cognitive deficits in autism spectrum disorder

被引：111
|
作者：
Banker, Sarah M. [1 ,3 ,5 ,6 ]
Gu, Xiaosi [1 ,2 ,5 ,6 ]
Schiller, Daniela [1 ,2 ,5 ,6 ]
Foss-Feig, Jennifer H. [2 ,3 ,4 ,6 ]
机构：
[1] Icahn Sch Med Mt Sinai, Nash Family Dept Neurosci, New York, NY 10029 USA
[2] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA
[3] Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA
[4] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA
[5] Icahn Sch Med Mt Sinai, Ctr Computat Psychiat, New York, NY 10029 USA
[6] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA
来源：
TRENDS IN NEUROSCIENCES | 2021年 / 44卷 / 10期
关键词：
DEFAULT MODE NETWORK; FUNCTIONAL CONNECTIVITY; SPATIAL NAVIGATION; BRAIN RESPONSES; EPISODIC MEMORY; PLACE-CELLS; CHILDREN; AMYGDALA; FMRI; ADULTS;
D O I：
10.1016/j.tins.2021.08.005
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Autism spectrum disorder (ASD) is characterized by hallmark impairments in social functioning. Nevertheless, nonsocial cognition, including hippocampusdependent spatial reasoning and episodic memory, is also commonly impaired in ASD. ASD symptoms typically emerge between 12 and 24 months of age, a time window associated with critical developmental events in the hippocampus. Despite this temporal overlap and evidence of hippocampal structural abnormalities in ASD individuals, relatively few human studies have focused on hippocampal function in ASD. Herein, we review the existing evidence for the involvement of the hippocampus in ASD and highlight the hippocampus as a promising area of interest for future research in ASD.
引用
收藏
页码：793 / 807
页数：15
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