Exhaled nitric oxide and bronchial reactivity during and after inhaled beclomethasone in mild asthma

被引:85
|
作者
Silkoff, PE [1 ]
McClean, PA [1 ]
Slutsky, AS [1 ]
Caramori, M [1 ]
Chapman, KR [1 ]
Gutierrez, C [1 ]
Zamel, N [1 ]
机构
[1] Univ Toronto, Fac Med, Div Resp Med, Toronto, ON, Canada
关键词
exhaled; nitric oxide; asthma; bronchial reactivity;
D O I
10.3109/02770909809071000
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The measurement of exhaled nitric oxide (ENO) is recognized as a marker of airway inflammation. ENO was measured in 10 nonsteroid-treated asthmatics at recruitment, during 3 weeks of inhaled beclomethasone (1000 mu g/day) and for 3 weeks after withdrawal. Baseline ENO was increased in asthma compared with nonasthmatics (85.0 +/- 54.5 vs. 24.5 +/- 14.8 ppb, p < 0.0001). After in haled steroid, there was no significant change in forced expiratory volume in 1 sec (FEV1) and forced vital capacity (FVC), but methacholine PC20 rose significantly (p = 0.0345). ENO (mean +/- SD; % baseline) fell after 1 week on steroid to 60.6 +/- 31.1 and rose to 95.3 +/- 46.1 at 1 week after withdrawal. ENO did not correlate with PC20 or FEV1. The changes in ENO and PC20 were inversely correlated (r(2) = 0.325). ENO may be an index of airway inflammation and therapeutic response in bronchial asthma.
引用
收藏
页码:473 / 479
页数:7
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