Copper-promoted C1-H amination of pyrrolo[1,2-a]quinoxaline with N-fluorobenzenesulfonimide

被引：9
|
作者：
Hao, Di [1 ]
Yang, Zhen [1 ]
Liu, Yali [1 ]
Li, Yang [1 ]
Liu, Yan [1 ]
Liu, Ping [1 ]
机构：
[1] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi City 832004, Peoples R China
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2022年 / 1267卷
基金：
中国国家自然科学基金;
关键词：
Pyrrolo[1; 2-a ]quinoxaline; N – fluorobenzenesulfonimide; C-Hamination; VITRO ANTIMALARIAL ACTIVITY; IN-VITRO; BIOLOGICAL EVALUATION; DERIVATIVES; INHIBITORS; FLUORINATION; IMIDATION;
D O I：
10.1016/j.molstruc.2022.133636
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A copper-promoted direct C1-amination of pyrrolo[1,2-a]quinoxalines with N-fluorobenzenesulfonimide (NFSI) has been achieved. A series of C1-aminated pyrrolo[1,2-a]quinoxalines were obtained with broad substrate scope and good functional group tolerance. Gram-scale synthesis and further derivation of this aminated product were also investigated. Mechanism studies suggest that this reaction probably under-goes a free-radical process.(c) 2022 Elsevier B.V. All rights reserved.
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页数：6
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