N-heterocyclic carbene catalyzed Aza-Morita-Baylis-Hillman reaction of cyclic enones with N-tosylarylimines

被引：109

作者：

He, Lin ^{[1
]}

Jian, Teng-Yue ^{[1
]}

Ye, Song ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100080, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 19期

关键词：

D O I：

10.1021/jo071247i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] N-Heterocyclic carbenes (NHCs) prove to be efficient catalysts for the aza-Morita-B aylis -Hillman (aza-MBH) reaction of cyclopent-2-en-1-one or cyclohex-2-en-1-one with a variety of N-tosylarylimines to give the aza-MBH adduct in high yields. Crossover experiments show NHC can add to N-tosylarylimines in a reversible manner, which allows the addition of NHC to cyclic enones and thus catalyzes the aza-Mortia- Baylis -Hillman reaction.

引用

页码：7466 / 7468

页数：3

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