PEG-grafted chitosan as an injectable thermoreversible hydrogel

被引：124
|
作者：
Bhattarai, N
Matsen, FA
Zhang, M [1 ]
机构：
[1] Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA
[2] Univ Washington, Dept Orthopaed & Sports Med, Seattle, WA 98195 USA
来源：
MACROMOLECULAR BIOSCIENCE | 2005年 / 5卷 / 02期
关键词：
biocompatibility; chitosan; hydrogels; poly(ethylene glycol); viscosity;
D O I：
10.1002/mabi.200400140
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
PEG-grafted chitosan was formulated such that its solution undergoes a thermally reversed phase transition from an injectable free-flowing solution at low temperature to a gel at body temperature. Aqueous solutions of PEG-grafted chitosan can be prepared at physiological pH values, thereby allowing safe incorporation of bioactive molecules. This injectable thermoreversible hydrogel is potentially suitable for a wide range of biomedical applications, particularly in sustained in vivo drug release and tissue engineering.
引用
收藏
页码：107 / 111
页数：5
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