Synthesis of 12-oxobenzo[c]phenanthridinones and 4-substituted 3-arylisoquinolones via Vilsmeier-Haack reaction

被引：28
|
作者：
Khadka, Daulat Bikram
Yang, Su Hui
Cho, Suk Hee
Zhao, Chao
Cho, Won-Jea [1 ]
机构：
[1] Chonnam Natl Univ, Coll Pharm, Kwangju 500757, South Korea
来源：
TETRAHEDRON | 2012年 / 68卷 / 01期
关键词：
12-Oxobenzo[c]phenanthridinone; 4-Substituted; 3-arylisoquinolone; Vilsmeier-Haack reaction; Mitsunobu reaction; Knoevenagel condensation; PROTOBERBERINE ALKALOIDS; BIOLOGICAL EVALUATION; DNA TOPOISOMERASES; INHIBITORS; FORMYLATION; ANALOGS;
D O I：
10.1016/j.tet.2011.10.053
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Vilsmeier-Haack reaction on 3-arylisoquinolones resulted in versatile 4-formylated 3-arylisoquinolones that were further derivatized into 12-oxobenzo[c]phenanthridinones, 4-alkoxymethyl-3-arylisoquinolones, 3aryl-4-phenoxymethylisoquinolones, 4-aminomethyl-3-arylisquinolone, and 3-isoquinolinyl-2-phenyl-acrylonitrile by different synthetic strategies. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：250 / 261
页数：12
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