Palladium-catalyzed reaction of 2-alkynylhalobenzene with 2-alkynylbenzamide: an efficient approach to indeno[1,2-c]azepin-3(2H)-ones

被引：40
|
作者：
Luo, Yong [1 ]
Wu, Jie [1 ,2 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 39期
基金：
中国国家自然科学基金;
关键词：
CASCADE REACTIONS; ORGANIC-SYNTHESIS; MULTICOMPONENT REACTION; HETEROCYCLIC SYNTHESIS; DOMINO REACTIONS; STRATEGIES; LACTAMS; DERIVATIVES; CYCLIZATION; GENERATION;
D O I：
10.1039/c1cc14480d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel and efficient route for rapid access to indeno[1,2-c]azepin-3(2H)-ones is described, which proceeds through a palladium-catalyzed tandem reaction of 2-alkynylhalobenzene with 2-alkynylbenzamide in the presence of PPh(3) or PCy(3). The indeno[1,2-c] azepin-3(2H)-ones which incorporate both indene and unsaturated seven-membered ring lactam skeletons are obtained in good to excellent yields.
引用
收藏
页码：11137 / 11139
页数：3
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