DJ-1 and Parkinson's Disease

被引：1
|
作者：
Qi Ting-Ting [1 ]
Lin Lin [1 ]
Liu Yun [1 ]
Jiang Yong [1 ]
机构：
[1] So Med Univ, Key Lab Funct Prote Guangdong Prov, Dept Pathophysiol, Guangzhou 510515, Guangdong, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2011年 / 38卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Parkinson's disease; DJ-1; oxidative stress; CYSTEINE-SULFINIC ACID; MITOCHONDRIAL LOCALIZATION; CRYSTAL-STRUCTURE; PROTEIN DJ-1; ACTIVATION; PARK7; GENE; SUMOYLATION; MUTATIONS; OXIDATION;
D O I：
10.3724/SP.J.1206.2010.00393
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Located in the cytoplasm, mitochondria and nucleus in the form of soluble dimers, DJ-1 is a recognized Parkinson's disease (PD)-related protein since its gene mutation leads to the early onset of autosomal recessive PD. Under oxidative stress which is closely related to the pathogenesis of PD, DJ-1 exerts its neuroprotective effects by sensing oxidative stress, changing gene expression, and participating in the regulation of AKT, ASK and other important signaling pathways.
引用
收藏
页码：293 / 298
页数：6
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