Nivolumab-induced Acute Fibrinous and Organizing Pneumonia (AFOP)

被引：22

作者：

Ishiwata, Tsukasa ^{[1
,2
]}

Ebata, Takahiro ^{[1
]}

Iwasawa, Shunichiro ^{[1
]}

Matsushima, Jun ^{[3
]}

Ota, Satoshi ^{[3
]}

Nakatani, Yukio ^{[3
]}

Tsushima, Kenji ^{[2
]}

Tada, Yuji ^{[2
]}

Tatsumi, Koichiro ^{[2
]}

Takiguchi, Yuichi ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Med Oncol, Chiba, Chiba, Japan

[2] Chiba Univ, Grad Sch Med, Dept Respirol, Chiba, Chiba, Japan

[3] Chiba Univ, Grad Sch Med, Dept Pathol, Chiba, Japan

来源：

INTERNAL MEDICINE | 2017年 / 56卷 / 17期

关键词：

melanoma; nivolumab; pneumonitis; acute fibrinous and organizing pneumonia; bronchoalveolar lavage; IMMUNE CHECKPOINT INHIBITORS; PATIENT; MELANOMA; DOCETAXEL;

D O I：

10.2169/internalmedicine.8271-16

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Although nivolumab is known to cause immune-related interstitial lung diseases (ILD), the detailed characteristics of ILD are still not fully understood. A 68-year-old man was treated with nivolumab because of unresectable sinonasal melanoma, he achieved a complete response soon after the initiation of the therapy and a complete response was thereafter maintained for 30 weeks until the patient experienced dyspnea of subacute onset. CT images revealed patchy infiltrates and ground-glass opacifications. The bronchoalveolar lavage fluid (BALF) contained elevated percentages of lymphocytes (53%) and neutrophils (30%). A transbronchial lung biopsy revealed intraalveolar fibrin balls without hyaline membranes, which was considered to be consistent with the pattern of acute fibrinous and organizing pneumonia (AFOP). This is the first report of AFOP induced by nivolumab.

引用

页码：2311 / 2315

页数：5

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