Matrix Regeneration Ability In Situ Induced by a Silk Fibroin Small-Caliber Artificial Blood Vessel In Vivo

被引:3
|
作者
Li, Helei [1 ]
Dai, Mengnan [1 ]
Li, Meng [1 ]
Meng, Lingpeng [1 ]
Yu, Yangxiao [1 ]
Xu, Jianmei [1 ]
Dong, Fenglin [2 ]
Fan, Qingmin [2 ]
Yin, Yin [3 ]
Wang, Aiqing [3 ]
Wang, Jiannan [1 ]
机构
[1] Soochow Univ, Coll Text & Clothing Engn, Suzhou 215123, Peoples R China
[2] Soochow Univ, Affiliated Hosp 1, Dept Ultrasonog, Suzhou 215006, Peoples R China
[3] Soochow Univ, Dept Med, Suzhou 215123, Peoples R China
基金
中国国家自然科学基金;
关键词
silk fibroin; small-caliber artificial vessels; ECM; matrix fiber self-assembly; VASCULAR GRAFTS; III COLLAGEN; DIAMETER; SCAFFOLDS; BIOMATERIALS; ELASTIN;
D O I
10.3390/polym14183754
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
The success of a small-caliber artificial vascular graft in the host in order to obtain functional tissue regeneration and remodeling remains a great challenge in clinical application. In our previous work, a silk-based, small-caliber tubular scaffold (SFTS) showed excellent mechanical properties, long-term patency and rapid endothelialization capabilities. On this basis, the aim of the present study was to evaluate the vascular reconstruction process after implantation to replace the common carotid artery in rabbits. The new tissue on both sides of the SFTSs at 1 month was clearly observed. Inside the SFTSs, the extracellular matrix (ECM) was deposited on the pore wall at 1 month and continued to increase during the follow-up period. The self-assembled collagen fibers and elastic fibers were clearly visible in a circumferential arrangement at 6 months and were similar to autologous blood vessels. The positive expression rate of Lysyl oxidase-1 (LOXL-1) was positively correlated with the formation and maturity of collagen fibers and elastic fibers. In summary, the findings of the tissue regeneration processes indicated that the bionic SFTSs induced in situ angiogenesis in defects.
引用
收藏
页数:14
相关论文
共 31 条
  • [1] Nano-cellulose coating small-caliber artificial blood vessel
    Wang Cong
    Ll Yuling
    Hong Feng
    Tang Shuijia
    Wang Yunyun
    [J]. ADVANCED TEXTILE MATERIALS, PTS 1-3, 2011, 332-334 : 1794 - +
  • [2] Construction and performance evaluation of Hep/silk-PLCL composite nanofiber small-caliber artificial blood vessel graft
    Kuang, Haizhu
    Wang, Yao
    Shi, Yu
    Yao, Wangchao
    He, Xi
    Liu, Xuezhe
    Mo, Xiumei
    Lu, Shuyang
    Zhang, Peng
    [J]. BIOMATERIALS, 2020, 259 (259)
  • [3] A BLOOD-VESSEL EQUIVALENT AS A SMALL-CALIBER VASCULAR PROSTHESIS
    DEARANI, J
    AXFORD, T
    DOURSOUNIAN, M
    WEINBERG, CB
    BELL, E
    KHURI, S
    [J]. CIRCULATION, 1990, 82 (04) : 32 - 32
  • [4] Cells and stimuli in small-caliber blood vessel tissue engineering
    Tresoldi, Claudia
    Pellegata, Alessandro Filippo
    Mantero, Sara
    [J]. REGENERATIVE MEDICINE, 2015, 10 (04) : 505 - 527
  • [5] SILKGRAFT, A SILK FIBROIN TUBULAR SCAFFOLD FOR THE REPAIR AND REGENERATION OF SMALL CALIBER BLOOD VESSELS: LONG-TERM IN VIVO STUDY
    Alessandrino, Antonio
    Biagiotti, Marco
    Bassani, Giulia
    Vincoli, Valentina
    Settembrini, Piergiorgio
    Settembrini, Alberto
    Freddi, Giuliano
    [J]. TISSUE ENGINEERING PART A, 2022, 28 : S623 - S623
  • [6] Preparation and Evaluation of Prototype of Woven Small-caliber Artificial Blood Vessels
    Yang Xiao-yuan
    Guan Guo-ping
    Wang Lu
    Peng Lei
    Wang Yin-yan
    Zhan Quan
    Li Yu-ling
    King, M. W.
    [J]. 2011 INTERNATIONAL FORUM ON BIOMEDICAL TEXTILE MATERIALS, PROCEEDINGS, 2011, : 433 - 437
  • [7] Three-Layered Silk Fibroin Tubular Scaffold for the Repair and Regeneration of Small Caliber Blood Vessels: From Design to in vivo Pilot Tests
    Alessandrino, Antonio
    Chiarini, Anna
    Biagiotti, Marco
    Dal Pra, Ilaria
    Bassani, Giulia A.
    Vincoli, Valentina
    Settembrini, Piergiorgio
    Pierimarchi, Pasquale
    Freddi, Giuliano
    Armato, Ubaldo
    [J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2019, 7
  • [8] Electrospun silk fibroin–gelatin composite tubular matrices as scaffolds for small diameter blood vessel regeneration
    Chiara Marcolin
    Lorenza Draghi
    MariaCristina Tanzi
    Silvia Faré
    [J]. Journal of Materials Science: Materials in Medicine, 2017, 28
  • [9] Gelatin/heparin coated bio-inspired polyurethane composite fibers to construct small-caliber artificial blood vessel grafts
    Xiang, Zehong
    Chen, Honghong
    Xu, Baofeng
    Wang, Haozheng
    Zhang, Tianci
    Guan, Xinghua
    Ma, Zhifang
    Liang, Kuntang
    Ab, Qiang Shi
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 269
  • [10] Improved Performance of Bacterial Nanocellulose Conduits by the Introduction of Silk Fibroin Nanoparticles and Heparin for Small-Caliber Vascular Graft Applications
    Bao, Luhan
    Hong, Feng F.
    Li, Geli
    Hu, Gaoquan
    Chen, Lin
    [J]. BIOMACROMOLECULES, 2021, 22 (02) : 353 - 364