Salvage Therapy of Extremely High-Risk and Resistant Gestational Trophoblastic Neoplasia with Gemcitabine, Oxaliplatin, and Paclitaxel

被引：0
|
作者：
Huang, Yujie [1 ]
Ying, Jun [1 ]
Zhao, Wei [1 ]
Qian, Jian-hua [1 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 1, Dept Gynecol, Coll Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China
来源：
JOURNAL OF REPRODUCTIVE MEDICINE | 2018年 / 63卷 / 11-12期
关键词：
chemotherapy; gemcitabine; gestational trophoblastic disease; gestational trophoblastic neoplasia; high risk cases; hysterectomy; oxaliplatin; paclitaxel; salvage therapy; trophoblastic neoplasms; MANAGEMENT;
D O I：
暂无
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
BACKGROUND: In extremely high-risk gestational trophoblastic neoplasia (GTN) and resistant patients, EMA-CO and EP-EMA. are used as first-line treatment. For patients who fail EMA-CO or EP-EMA, therapeutic options are very limited. CASES: We report 3 cases of GTN classified as extremely high risk or resistant GTN. The patients all failed EMA-CO or EMA-EP regimen as well as additional standard chemotherapy. They were treated with gemcitabine, oxaliplatin, and paclitaxel regimen as salvage therapy. Two of the patients responded to the treatment. CONCLUSION: Multiagent chemotherapy is the treatment of choice for extremely high-risk GTN and resistant patients. Gemcitabine, oxaliplatin, and paclitaxel regimen should be considered as a salvage therapy in patients after failing EMA-CO or EMA-EP regimen.
引用
收藏
页码：530 / 534
页数：5
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