Transcriptome profiling reveals a novel role for trichostatin A in antagonizing histone chaperone Chz1 mediated telomere anti-silencing

被引：7
|
作者：
Wan, Yakun [1 ]
Chen, Weiming [2 ]
Xing, Jie [3 ]
Tan, Jinyin [1 ]
Li, Bing [1 ]
Chen, Huiying [1 ]
Lin, Zhanxian [2 ]
Chiang, Jung-Hsien [2 ]
Ramsey, Saleem [4 ]
机构：
[1] Southeast Univ, Inst Life Sci, Key Lab Dev Genes & Human Dis, Minist Educ, Nanjing 210009, Peoples R China
[2] Natl Cheng Kung Univ, Dept Comp Sci & Informat Engn, Tainan 70101, Taiwan
[3] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Peoples R China
[4] Inst Syst Biol, Seattle, WA 98103 USA
来源：
FEBS LETTERS | 2011年 / 585卷 / 15期
基金：
中国国家自然科学基金;
关键词：
Histone chaperone; Histone deacetylase inhibitor; Telomere silencing; Epigenetic regulation; SACCHAROMYCES-CEREVISIAE; DEACETYLASE INHIBITORS; GENOME-WIDE; NONHISTONE PROTEINS; NUCLEOSOME DYNAMICS; ANTICANCER AGENTS; CHROMATIN; ACETYLATION; YEAST; ASF1;
D O I：
10.1016/j.febslet.2011.06.036
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The histone chaperones play an important role in chromatin assembly and disassembly during replication and transcription. We have assessed the global roles of histone chaperones in Saccharomyces cerevisiae. Microarray transcriptional analyzes indicate that histone chaperones have their own specific target genes, and various histone chaperones have partially overlapping functions during transcriptional regulation. The histone deacetylase inhibitor TSA and histone chaperones Asf1, Vps75 and Rtt106 can function in parallel pathways to regulate transcription. Moreover, TSA can specifically antagonize histone chaperone Chz1-mediated telomere anti-silencing. This study demonstrates that a mutual cross-talk mechanism exists between histone chaperones and histone deacetylation in transcriptional regulation. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码：2519 / 2525
页数：7
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