New facile and mild synthesis of 2-substituted oxazolopyridines

被引：35
|
作者：
Heuser, S
Keenan, M
Weichert, AG
机构：
[1] Lilly Forsch GmbH, Div Eli Lilly Res Labs, D-22419 Hamburg, Germany
[2] Lilly Res Ctr Ltd, Windlesham GU20 6PH, Surrey, England
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 52期
关键词：
oxazolopyridines; heterocycles; carboxylic acids; 2-amino-pyridinol; solid-phase synthesis;
D O I：
10.1016/j.tetlet.2005.10.109
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new, two-step synthesis of oxazolopyridines is described. The synthesis involving amide formation between o-aminopyridinols and aliphatic or aromatic carboxylic acids followed by condensation with hexachloroethane/triphenylphosphine takes place at room temperature and thereby gives mild access to all regioisomeric, 2-substituted oxazolopyridines in good yields. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：9001 / 9004
页数：4
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