Platelet activation and function during eltrombopag treatment in immune thrombocytopenia

被引：25

作者：

Haselboeck, Johanna ^{[2
]}

Pabinger, Ingrid ^{[2
]}

Ay, Cihan ^{[2
]}

Koder, Silvia ^{[2
]}

Panzer, Simon ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Bloodgrp Serol & Transfus Med, A-1090 Vienna, Austria

[2] Med Univ Vienna, Div Hematol & Hemostaseol, Dept Med 1, A-1090 Vienna, Austria

来源：

ANNALS OF HEMATOLOGY | 2012年 / 91卷 / 01期

关键词：

Eltrombopag; Immune thrombocytopenia; ITP; Platelet function; Platelet activation; TISSUE FACTOR; P-SELECTIN; DOUBLE-BLIND; IN-VIVO; THROMBOPOIETIN; ROMIPLOSTIM; PROGRESS; PURPURA;

D O I：

10.1007/s00277-011-1249-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We monitored platelet activation by means of P-selectin and platelet monocyte aggregates (PMA) and platelet function by whole blood multiple electrode aggregometry and platelet adhesion under high shear in chronic immune thrombocytopenia patients to define changes in platelet activation during treatment with eltrombopag. Overall, platelet activation and function normalized with increasing platelet counts. However, P-selectin, which was already elevated before treatment, and PMA increased further transiently during the first weeks. The increases in P-selectin and in PMA indicate ongoing platelet activation during the early period of treatment.

引用

页码：109 / 113

页数：5

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