Melatonin May Increase Anticancer Potential of Pleiotropic Drugs

被引：11

作者：

Bojkova, Bianka ^{[1
]}

Kubatka, Peter ^{[2
,3
]}

Qaradakhi, Tawar ^{[4
]}

Zulli, Anthony ^{[4
]}

Kajo, Karol ^{[5
,6
]}

机构：

[1] Pavol Jozef Safarik Univ Kosice, Fac Sci, Inst Biol & Ecol, Dept Anim Physiol, Srobarova 2, Kosice, Slovakia

[2] Comenius Univ, Jessenius Fac Med, Dept Med Biol, Mala Hora 4, Martin 03601, Slovakia

[3] Comenius Univ, Jessenius Fac Med, Biomed Ctr Martin, Dept Expt Carcinogenesis,Div Oncol, Mala Hora 4C, Martin, Slovakia

[4] Victoria Univ, Inst Hlth & Sport IHES, Melbourne, Vic 3011, Australia

[5] St Elisabeth Oncol Inst, Heydukova 10, Bratislava 81108, Slovakia

[6] Slovak Acad Sci, Biomed Res Ctr, Dubravska Cesta 9, Bratislava 84505, Slovakia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 12期

关键词：

melatonin; cancer; NSAIDs; statins; antidiabetics; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PINEAL HORMONE MELATONIN; ACTIVATED RECEPTOR-GAMMA; INDUCED MAMMARY CARCINOGENESIS; COLORECTAL-CANCER CELLS; DI BELLA METHOD; INHIBIT SKIN CARCINOGENESIS; PHASE-II TRIAL; BREAST-CANCER; PROSTATE-CANCER;

D O I：

10.3390/ijms19123910

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Melatonin (N-acetyl-5-methoxytryptamine) is not only a pineal hormone, but also an ubiquitary molecule present in plants and part of our diet. Numerous preclinical and some clinical reports pointed to its multiple beneficial effects including oncostatic properties, and as such, it has become one of the most aspiring goals in cancer prevention/therapy. A link between cancer and inflammation and/or metabolic disorders has been well established and the therapy of these conditions with so-called pleiotropic drugs, which include non-steroidal anti-inflammatory drugs, statins and peroral antidiabetics, modulates a cancer risk too. Adjuvant therapy with melatonin may improve the oncostatic potential of these drugs. Results from preclinical studies are limited though support this hypothesis, which, however, remains to be verified by further research.

引用

页数：34

共 50 条

[1] Curcuminoids as Anticancer Drugs: Pleiotropic Effects, Potential for Metabolic Reprogramming and Prospects for the Future
Pouliquen, Daniel L.
Troselj, Koraljka Gall
Anto, Ruby John
PHARMACEUTICS, 2023, 15 (06)
[2] Dual inhibition of P-glycoprotein and midkine may increase therapeutic effects of anticancer drugs
Aynacioglu, A. Sukru
Bilir, Ayhan
Kadomatsu, Kenji
MEDICAL HYPOTHESES, 2017, 107 : 26 - 28
[3] Melatonin, a potential new anticancer drug in animals
Zan, Rafal
Rolinski, Zbigniew
Kowalski, Cezary
Burmanczuk, Artur
MEDYCYNA WETERYNARYJNA-VETERINARY MEDICINE-SCIENCE AND PRACTICE, 2012, 68 (06): : 343 - 348
[4] Pleiotropic Effects of Melatonin
Mahmood, Danish
DRUG RESEARCH, 2019, 69 (02) : 65 - 74
[5] Melatonin - a pleiotropic hormone
Brzeczek, Maciej
Slonka, Karina
Hyla-Klekot, Lidia
PEDIATRIA I MEDYCYNA RODZINNA-PAEDIATRICS AND FAMILY MEDICINE, 2016, 12 (02): : 127 - 133
[6] Scheduling of anticancer drugs Timing may be everything
Van der Veldt, Astrid A. M.
Lammertsma, Adriaan A.
Smit, Egbert F.
CELL CYCLE, 2012, 11 (23) : 4339 - 4343
[7] Melatonin as a Pleiotropic Molecule with Therapeutic Potential for Type 2 Diabetes and Cancer
Wojcik, Marzena
Krawczyk, Michal
Wojcik, Pawel
Cypryk, Katarzyna
Wozniak, Lucyna Alicja
CURRENT MEDICINAL CHEMISTRY, 2017, 24 (35) : 3829 - 3850
[8] Analogs of staurosporine: Potential anticancer drugs?
Gescher, A
GENERAL PHARMACOLOGY, 1998, 31 (05): : 721 - 728
[9] Three steps to potential anticancer drugs
Brodie, Rebecca
CHEMISTRY WORLD, 2010, 7 (06): : 20 - 20
[10] Radiosensitizing Potential of Epigenetic Anticancer Drugs
De Schutter, Harlinde
Nuyts, Sandra
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2009, 9 (01) : 99 - 108

← 1 2 3 4 5 →