The effects of chronic Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) use on cerebral glucose metabolism in multiple sclerosis: a pilot study

被引：4
|
作者：
Workman, Craig D. [1 ]
Kindred, John H. [2 ]
Ponto, Laura L. Boles [3 ]
Kamholz, John [4 ]
Rudroff, Thorsten [1 ,4 ]
机构：
[1] Univ Iowa, Dept Hlth & Human Physiol, Iowa City, IA 52242 USA
[2] Med Univ South Carolina, Dept Phys Therapy, Charleston, SC 29425 USA
[3] Univ Iowa Hlth Clin, Dept Radiol, Iowa City, IA 52242 USA
[4] Univ Iowa Hlth Clin, Dept Neurol, Iowa City, IA 52242 USA
来源：
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM | 2020年 / 45卷 / 04期
关键词：
multiple sclerosis; PET scan; cannabis; THC; CBD; chronic effects; MARIJUANA; PEOPLE; TRIAL;
D O I：
10.1139/apnm-2019-0634
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
This exploratory pilot study investigated the effects of chronic Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on cerebral glucose metabolism in people with multiple sclerosis (PwMS). Compared with nonusers, THC users had hypermetabolism of 3 regions (p < 0.039, d >1.17) in left temporal areas, while CBD users had hypometabolism of 5 regions (p < 0.032, d > 1.31) in left temporal areas. This study highlights the need to discriminate between THC and CBD in future cannabis studies. Novelty Chronic THC and CBD use had disparate effects on cerebral glucose metabolism in PWMS.
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页码：450 / 452
页数：3
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