Acute Megakaryoblastic Leukemia Harboring a Subclone Expressing BCR-ABL1 Fusion Gene Product

被引：0

作者：

Kashima, Emiko ^{[1
]}

Nakano, Eri ^{[1
]}

Watanabe, Yasuyuki ^{[1
]}

Imai, Hiroshi ^{[2
]}

Oka, Koji ^{[1
]}

Kageyama, Shinichi ^{[1
]}

Tanaka, Isao ^{[1
]}

机构：

[1] Suzuka Kaisei Hosp, Dept Hematol, Suzuka, Japan

[2] Mie Univ Hosp, Pathol Div, Tsu, Mie, Japan

来源：

INTERNAL MEDICINE | 2021年 / 60卷 / 22期

关键词：

Ph plus AML; acute megakaryoblastic leukemia; BCR-ABL1 fusion gene; ACUTE MYELOID-LEUKEMIA; DISTINCT; AML;

D O I：

10.2169/internalmedicine.7335-21

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute myeloid leukemia (AML) with BCR-ABL1, also termed Philadelphia chromosome-positive AML (Ph + AML), is a rare leukemia subtype classified by the World Health Organization in 2016. The characteristics of Ph+ AML have not been fully identified yet. We herein report a patient with Ph+ AML who phenotypically exhibited megakaryoblastic characteristics, FAB:M7 and harbored a subclone expressing BCR-ABL1 gene fusion products. This case suggests that BCR-ABL1 was acquired as a subclone due to a secondary event that might have occurred late during leukemia evolution. Our findings may aid in deciphering the mechanism underlying Ph+ AML development in future studies.

引用

页码：3609 / 3614

页数：6

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