Synthesis of novel silylated 1,2,4-triazin-5-ones

被引：8
|
作者：
Bolm, C
Kasyan, A
Saladin, S
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52056 Aachen, Germany
[2] ProBioGen AG, D-13086 Berlin, Germany
[3] Beiersdorf AG, D-20245 Hamburg, Germany
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 23期
关键词：
alpha-silyl-alpha-keto esters; iminations; 1,2,4-triazin-5-ones; thiosemicarbazones; intramolecular cyclization;
D O I：
10.1016/j.tetlet.2005.04.021
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of various alpha-silyl-alpha-keto esters with thiosemicarbazide at 50 degrees C in ethyl acetate was found to give alpha-silyl-substituted thiosemicarbazone-acetic acid esters in good yield. These may then be converted to their corresponding silyl-substituted 1,2,4-triazin-5-ones by cyclization under basic conditions. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4049 / 4051
页数：3
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