Neurocognitive Profile of the Post-COVID Condition in Adults in Catalonia-A Mixed Method Prospective Cohort and Nested Case-Control Study: Study Protocol

被引：3

作者：

Dacosta-Aguayo, Rosalia ^{[1
,2
,3
]}

Lamonja-Vicente, Noemi ^{[1
,4
]}

Chacon, Carla ^{[1
,4
]}

Amalia Carrasco-Ribelles, Lucia ^{[1
]}

Montero-Alia, Pilar ^{[1
,4
,5
,6
]}

Costa-Garrido, Anna ^{[1
]}

Garcia-Sierra, Rosa ^{[1
,5
,7
]}

Lopez-Lifante, Victor M. ^{[1
,4
,8
]}

Moreno-Gabriel, Eduard ^{[1
,4
,5
,9
]}

Massanella, Marta ^{[10
,11
,12
,13
]}

Puig, Josep ^{[2
]}

Munoz-Moreno, Jose A. ^{[14
,15
]}

Mateu, Lourdes ^{[10
,11
,12
,13
,14
,16
]}

Prats, Anna ^{[14
]}

Rodriguez, Carmina ^{[1
,4
,5
,17
]}

Mataro, Maria ^{[3
]}

Prado, Julia G. ^{[10
,11
,12
,18
]}

Martinez-Caceres, Eva ^{[19
,20
,21
]}

Violan, Concepcion ^{[1
,4
,7
,22
]}

Toran-Monserrat, Pere ^{[1
,4
,5
,18
,23
]}

机构：

[1] Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Unitat Suport Recerca Metropolitana Nord, Mataro 08303, Spain

[2] Germans Trias & Pujol Res Inst, Comparat Med & Bioimaging Ctr CMCiB, Badalona 08916, Spain

[3] Univ Barcelona, Dept Clin Psychol & Psychobiol, Barcelona 08035, Spain

[4] Inst Catala Salut, Direccio Atencio Primaria Metropolitana Nord, Mataro 08916, Spain

[5] Multidisciplinary Res Grp Hlth & Soc GREMSAS 2017, Barcelona 08007, Spain

[6] Inst Catala Salut, Ctr Atencio Primaria La Riera Mataro 1, Barcelona 08302, Spain

[7] Univ Autonoma Barcelona, Fac Med, Nursing Dept, Barcelona 08193, Spain

[8] Palau Solita Plegamans Inst Catala Salut, Palau Solita Healthcare Ctr, Barcelona 08124, Spain

[9] Univ Autonoma Barcelona, Dept Social Psychol, Bellaterra 08193, Spain

[10] IrsiCaixa Aids Res Inst, Can Ruti Campus, Badalona 08916, Spain

[11] Germans Trias & Pujol Hlth Res Inst IGTP, Can Ruti Campus, Badalona 08916, Spain

[12] Inst Salud Carlos III ISCIII, Ctr Invest Biomed Red Enfermedades Infecciosas CI, Madrid 28029, Spain

[13] Univ Vic, Cent Univ Catalonia UVic UCC, Vic 08500, Spain

[14] Germans Trias & Pujol Hosp, FIGHT AIDS FDN FLS, Infect Dis Dept, Can Ruti Campus, Badalona 08916, Spain

[15] Univ Oberta Catalunya UOC, Fac Psicol & Ciencies Educ, Barcelona 08035, Spain

[16] Univ Autonoma Barcelona, Germans Trias & Pujol Hosp, Badalona 08916, Spain

[17] Inst Catala Salut, St Fost Campcentelles Healthcare Ctr, St Fost Campcentelles, Barcelona 08105, Spain

[18] Univ Autonoma Barcelona, Germans Trias & Pujol Res Inst, Badalona 08916, Spain

[19] Univ Autonoma Barcelona, Immunol Dept, FOCIS Ctr Excellence, Cerdanyola Del Valles 08193, Spain

[20] Hosp Badalona Germans Trias & Pujol, Immunol Div, Lab Clin Metropolitana Nord LCMN, Badalona 08916, Spain

[21] Univ Autonoma Barcelona, Fac Med, Dept Med, Bellaterra 08193, Spain

[22] Univ Autonoma Barcelona, Bellaterra 08193, Spain

[23] Univ Girona, Fac Med, Dept Med, Girona 17003, Spain

来源：

VACCINES | 2022年 / 10卷 / 06期

关键词：

post-COVID condition; cognitive symptoms; neuropsychologic symptoms; quality of life; retinography; posturography; magnetic resonance imaging; immune response; inflammation; CORONAVIRUS; QUESTIONNAIRE; RELIABILITY; DEPRESSION;

D O I：

10.3390/vaccines10060849

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The diagnosis of the post-COVID condition is usually achieved by excluding other diseases; however, cognitive changes are often found in the post-COVID disorder. Therefore, monitoring and treating the recovery from the post-COVID condition is necessary to establish biomarkers to guide the diagnosis of symptoms, including cognitive impairment. Our study employs a prospected cohort and nested case-control design with mixed methods, including statistical analyses, interviews, and focus groups. Our main aim is to identify biomarkers (functional and structural neural changes, inflammatory and immune status, vascular and vestibular signs and symptoms) easily applied in primary care to detect cognitive changes in post-COVID cases. The results will open up a new line of research to inform diagnostic and therapeutic decisions with special considerations for cognitive impairment in the post-COVID condition.

引用

页数：14

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