Protein acetylation in synaptic plasticity and memory

被引:43
|
作者
Sharma, Shiv K. [1 ]
机构
[1] Natl Brain Res Ctr, Manesar 122050, Haryana, India
来源
关键词
Histone acetylation; Deacetylase; Long-term potentiation; Memory; Synaptic plasticity; LONG-TERM-MEMORY; RUBINSTEIN-TAYBI-SYNDROME; FACTOR-KAPPA-B; HISTONE ACETYLATION; ACETYLTRANSFERASE ACTIVITY; INHIBITORY CONSTRAINTS; EPIGENETIC MECHANISMS; CHROMATIN-STRUCTURE; CONDITIONED FEAR; GENE-EXPRESSION;
D O I
10.1016/j.neubiorev.2010.02.009
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Posttranslational modifications of proteins regulate various processes in the cells. The seminal role of phosphorylation in synaptic plasticity and memory has been established using several different model systems. Recently, an important role for another posttranslational modification, acetylation, particularly of histones, has emerged in these processes. This review focuses on the role of activity-dependent protein acetylation in synaptic plasticity and memory. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1234 / 1240
页数:7
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