Lusutrombopag Reliably Increases Platelet Counts for up to 3 Weeks in Chronic Liver Disease Patients with Thrombocytopenia Undergoing Invasive Procedures Regardless of Baseline Platelet Counts: Results from Two Phase 3 Trials

被引：0

作者：

Brown, Robert S., Jr. ^{[1
]}

Imawari, Michio ^{[2
]}

Izumi, Namiki ^{[3
]}

Osake, Yukio ^{[4
]}

Bentley, Roy ^{[5
]}

Baykal, Tolga ^{[5
]}

Ochiai, Toshimitsu ^{[6
]}

Kano, Takeshi ^{[6
]}

机构：

[1] Weill Cornell Med Coll, New York, NY USA

[2] Shin Yurigaoka Gen Hosp, Inst Gastrointestinal & Liver Dis, Kawasaki, Kanagawa, Japan

[3] Musashino Hosp, Japanese Red Cross Soc, Mitaka, Tokyo, Japan

[4] Meiwa Hosp, Nishinomiya, Hyogo, Japan

[5] Shionogi Inc, Osaka, Japan

[6] Shionogi & Co Ltd, Osaka, Japan

来源：

HEPATOLOGY | 2018年 / 68卷

关键词：

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

2069

引用

页码：1178A / 1179A

页数：2

共 23 条

[1] Lusutrombopag Is a Safe and Efficacious Treatment Option for Thrombocytopenia in Patients with Chronic Liver Disease Undergoing Invasive Procedures: A Pooled Analysis of Two Phase 3 Trials
Brown, Robert S., Jr.
Imawari, Michio
Izumi, Namiki
Osake, Yukio
Ochiai, Toshimitsu
Kano, Takeshi
Bentley, Roy
Peck-Radosavljevic, Markus
HEPATOLOGY, 2018, 68 : 1148A - 1148A
[2] Superiority of Avatrombopag to Placebo in Increasing Platelet Counts in Patients with Chronic Liver Disease-Associated Thrombocytopenia Undergoing Scheduled Procedures: Results from 2, Phase 3 Randomized Studies
Terrault, Norah
Kuter, David J.
Izumi, Namiki
Kayali, Zeid
Mitrut, Paul
Tak, Won Young
Bibbiani, Francesco
BLOOD, 2017, 130
[3] Platelet Response to Lusutrombopag, a Thrombopoietin Receptor Agonist, in Patients with Chronic Liver Disease and Thrombocytopenia Undergoing Non-Emergency Invasive Procedures: Results from a Phase 3 Randomized, Double-Blind, Placebo-Controlled Study
Afdhal, Nezam
Duggal, Ajay
Ochiai, Toshimitsu
Motomiya, Tomoko
Kano, Takeshi
Nagata, Tsutae
Peck-Radosavljevic, Markus
BLOOD, 2017, 130
[4] SUPERIORITY OF AVATROMBOPAG TO PLACEBO IN INCREASING PLATELET COUNTS AND REDUCING PLATELET TRANSFUSIONS IN PATIENTS WITH CHRONIC LIVER DISEASE-ASSOCIATED THROMBOCYTOPENIA UNDERGOING SCHEDULED PROCEDURES-POOLED ANALYSIS OF 2 RANDOMIZED PHASE 3 STUDIES
Poordad, Fred
Vredenburg, Michael
Allen, Lee F.
Aggarwal, Kavita
Alkhouri, Naim
GASTROENTEROLOGY, 2018, 154 (06) : S529 - S529
[5] Avatrombopag, a Novel Thrombopoietin Receptor Agonist, Increases Platelet Counts without Increasing Platelet Activation in Patients with Thrombocytopenia Due to Chronic Liver Disease
Frelinger, Andrew L., III
Koganov, Elena Smolensky
Forde, Emma E.
Carmichael, Sabrina L.
Michelson, Alan D.
BLOOD, 2017, 130
[6] Safety and effectiveness of lusutrombopag in Japanese chronic liver disease patients with thrombocytopenia undergoing invasive procedures: Interim results of a postmarketing surveillance
Sasaki, Ritsue
Shiino, Chikako
Imawari, Michio
Bentley, Roy
Cai, Bin
Yoshida, Manami
Afdhal, Nezam
HEPATOLOGY RESEARCH, 2019, 49 (10) : 1169 - 1181
[7] Splenomegaly status does not impact the efficacy of avatrombopag in increasing platelet counts and reducing platelet transfusions or rescue procedures for bleeding in chronic liver disease patients with thrombocytopenia
Qamar, Amir
Aggarwal, Kavita
Vredenburg, Michael
Tian, Wei
Allen, Lee F.
JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E690 - E690
[8] Is platelet monitoring during 7-day lusutrombopag treatment necessary in chronic liver disease patients with thrombocytopenia undergoing planned invasive procedures? A phase IIIb open-label study
Numata, Kazushi
Tanaka, Katsuaki
Katsube, Takayuki
Ochiai, Toshimitsu
Fukuhara, Takahiro
Kano, Takeshi
Osaki, Yukio
Izumi, Namiki
Imawari, Michio
HEPATOLOGY RESEARCH, 2020, 50 (10) : 1141 - 1150
[9] ORAL ELTROMBOPAG INCREASES PLATELET COUNTS AND REDUCES BLEEDING IN CHRONIC ITP PATIENTS: POOLED RESULTS OF PHASE 11 AND PHASE III TRIALS
Saleh, M. N.
Bussel, J. B.
Stone, N.
Mayer, B.
Jenkins, J.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 : 124 - 124
[10] EFFICACY OF ORAL THROMBOPOIETIN RECEPTOR AGONIST LUSUTROMBOPAG IN CHRONIC LIVER DISEASE PATIENTS UNDERGOING A GASTROINTESTINAL PROCEDURE: RESULTS FROM TWO PHASE 3 CLINICAL TRIALS
Moehlen, Martin
Semaan, Mark
Kano, Takeshi
Ochiai, Toshimitsu
GASTROENTEROLOGY, 2020, 158 (06) : S614 - S614

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