Oridonin-induced apoptosis in SW620 human colorectal adenocarcinoma cells

被引：19

作者：

Ji, Zhe ^{[1
,2
]}

Tang, Qingjiu ^{[1
]}

Zhang, Jinsong ^{[1
]}

Yang, Yan ^{[1
]}

Liu, Yanfang ^{[1
]}

Pan, Yingjie ^{[3
]}

机构：

[1] Shanghai Acad Agr Sci, Inst Edible Fungi, Natl Engn Res Ctr Edible Fungi,Shanghai Key Lab A, Key Lab Appl Mycol Resources & Utilizat,Minist Ag, Shanghai 201106, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China

[3] Shanghai Fisheries Univ, Shanghai 200090, Peoples R China

来源：

ONCOLOGY LETTERS | 2011年 / 2卷 / 06期

基金：

美国国家科学基金会; 中国博士后科学基金;

关键词：

apoptosis; caspase-3; oridonin; CANCER-CELLS; ANTITUMOR-ACTIVITY; PROSTATE-CANCER; PC-SPES; CASPASES; GROWTH; PROLIFERATION; INHIBITION; ACTIVATION; DEATH;

D O I：

10.3892/ol.2011.408

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oridonin, a diterpenoid isolated from Rabdosia rubescens (Hemsl.) Hara, inhibited the growth of human tumor cell lines SW620 (colon), MCF-7 (breast) and K562 (bone marrow), and induced significant levels of apoptosis in SW620. Morphological changes indicative of cell apoptosis were observed after the cells were exposed to oridonin for 24 h. Growth inhibition was associated with G1 phase arrest, and with time- and dose-dependent increases in caspase-3 activity. We therefore conclude that oridonin inhibits the proliferation of SW620 cells by induction of apoptosis via the activation of caspase-3. Our data suggest that oridonin may have significant potential as an anti-colorectal adenocarcinoma agent.

引用

页码：1303 / 1307

页数：5

共 50 条

[1] A rice bran polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis
Kong, Carrie K. L.
Lam, W. S.
Chiu, Lawrence C. M.
Ooi, Vincent E. C.
Sun, Samuel S. M.
Wong, Yum-Shing
[J]. BIOCHEMICAL PHARMACOLOGY, 2009, 77 (09) : 1487 - 1496
[2] Antimycin induces apoptosis in rapamycin resistant SW620 colorectal cancer cells
Teran, Blanca Lucila
Thomas, Janice
[J]. FASEB JOURNAL, 2013, 27
[3] Oridonin-induced apoptosis of Jurkat cells and its mechanism
Liu J.
Huang R.
Lin D.
Wu X.
Wu X.
Lu H.
Pan X.
Peng J.
Li M.
Lin Q.
[J]. Comparative Clinical Pathology , 2004, 13 (2) : 65 - 69
[4] Manganese oxide nanoparticles inhibit selectively the in vitro and in vivo growth of human colorectal SW620 adenocarcinoma cells
Razumov, Ivan Alekseevich
Troitskii, Sergei Yurievich
Solovieva, Olga Igorevna
Boldyrev, Nikita Dmitrievich
Zavjalov, Evgenii Leonidovich
[J]. ADVANCES IN NATURAL SCIENCES-NANOSCIENCE AND NANOTECHNOLOGY, 2022, 13 (02)
[5] Proteomic analysis of oridonin-induced apoptosis in multiple myeloma cells
Zhao, Jing
Zhang, Mei
He, Pengcheng
Zhao, Junjie
Chen, Ying
Qi, Jun
Wang, Yuan
[J]. MOLECULAR MEDICINE REPORTS, 2017, 15 (04) : 1807 - 1815
[6] Baicalin Induces Apoptosis in SW620 Human Colorectal Carcinoma Cells in Vitro and Suppresses Tumor Growth in Vivo
Chen, Wen-Cheng
Kuo, Tsu-Hsiang
Tzeng, Yi-Shiuan
Tsai, Ying-Chieh
[J]. MOLECULES, 2012, 17 (04): : 3844 - 3857
[7] Emodin suppresses Wnt signaling in human colorectal cancer cells SW480 and SW620
Pooja, Thacker
Karunagaran, Devarajan
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 742 : 55 - 64
[8] Attack the Tumor Counterattack-C-Flip Expression in Jurkat-T-Cells Protects Against Apoptosis Induced by Coculture with SW620 Colorectal Adenocarcinoma Cells
Steiert, Andreas E.
Sendler, Daniel
Burke, Willam F.
Choi, Claudia Y.
Reimers, Kerstin
Vogt, Peter M.
[J]. JOURNAL OF SURGICAL RESEARCH, 2012, 176 (01) : 133 - 140
[9] Effect of Broccoli Extracts on Proliferation Inhibition and Apoptosis in the Colon SW620 Cells
Wen, Yan
Yuan, Jin-Hao
Zhou, Qin-Yong
Wang, Wen-Bing
Xu, Xiao-Feng
[J]. INTERNATIONAL JOURNAL OF AGRICULTURE AND BIOLOGY, 2019, 22 (04) : 769 - 773
[10] Resveratrol induces mitochondrial respiration and apoptosis in SW620 colon cancer cells
del Mar Blanquer-Rossello, Ma
Hernandez-Lopez, Reyniel
Roca, Pilar
Oliver, Jordi
Valle, Adamo
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2017, 1861 (02): : 431 - 440

← 1 2 3 4 5 →