Codonopsis pilosula (Franch) Nannf total alkaloids potentiate neurite outgrowth induced by nerve growth factor in PC12 cells

被引：0
|
作者：
Liu, JH [1 ]
Bao, YM [1 ]
Song, JJ [1 ]
An, LJ [1 ]
机构：
[1] Dalian Univ Technol, Dept Biochem Engn, Dalian 116024, Peoples R China
来源：
ACTA PHARMACOLOGICA SINICA | 2003年 / 24卷 / 09期
关键词：
Codonopsis; alkaloids; mitogen-activated protein kinases; nerve growth factors; neurites;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
AIM: To explore the effect of Codonopsis pilosula (Franch) Nannf total alkaloids (DSA) on differentiation induced by nerve growth factor (NGF) in PC12 cells. METHODS: After culturing PC12 cells with DSA in the presence or absence of NGF, neurite outgrowth in PC 12 cells and correlated protein kinases were assayed. RESULTS: DSA alone did not exhibit neuritogenic activity, but caused a significant enhancement of NGF (2 mug/L)-induced neurite outgrowth in PC12 cells, and increased the phosphorylation of mitogen-activated protein kinase (MAPK). Furthermore, this enhancing effect was completely blocked by a specific MAPK kinase inhibitor, PD98059. CONCLUSION: DSA enhanced the NGF-induced neurite outgrowth in PC12 cells by amplifying an up-stream step of the MAPK-dependent signaling pathway.
引用
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页码：913 / 917
页数：5
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