Single-File Diffusion of Protein Drugs through Cylindrical Nanochannels

被引：188

作者：

Yang, Seung Yun ^{[1
,2
]}

Yang, Jeong-A ^{[3
]}

Kim, Eung-Sam ^{[4
,5
]}

Jeon, Gumhye ^{[1
,2
]}

Oh, Eun Ju ^{[3
]}

Choi, Kwan Yong ^{[4
,5
]}

Hahn, Sei Kwang ^{[3
]}

Kim, Jin Kon ^{[1
,2
]}

机构：

[1] Pohang Univ Sci & Technol, Natl Creat Res Ctr Block Copolymer Self Assembly, Dept Environm Sci & Engn, Kyungbuk 790784, South Korea

[2] Pohang Univ Sci & Technol, Dept Chem Engn, Kyungbuk 790784, South Korea

[3] Pohang Univ Sci & Technol, Dept Mat Sci & Engn, Kyungbuk 790784, South Korea

[4] Pohang Univ Sci & Technol, Dept Life Sci, Kyungbuk 790784, South Korea

[5] Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Kyungbuk 790784, South Korea

来源：

ACS NANO | 2010年 / 4卷 / 07期

关键词：

protein drug; nanochannels; block copolymer; single-file diffusion; controlled drug delivery; BLOCK-COPOLYMER; SEPARATION; MEMBRANES; FORMULATION; FILTRATION; STABILITY; SIZE;

D O I：

10.1021/nn100464u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new drug delivery device using cylindrical block copolymer nanochannels was successfully developed for controlled protein drug delivery applications. Depending on the hydrodynamic diameter of the protein drugs, the pore size in cylindrical nanochannels could be controlled precisely down to 6 nm by Au deposition. Zero-order release of bovine serum albumin (BSA) and human growth hormone (hGH) by single-file diffusion, which has been observed for gas diffusion through zeolite pores, was realized up to 2 months without protein denaturation. Furthermore, a nearly constant in vivo release of hGH from the drug delivery nanodevice implanted to Sprague-Dawley (SD) rats was continued up to 3 weeks, demonstrating the feasibility for long-term controlled delivery of therapeutic protein drugs.

引用

页码：3817 / 3822

页数：6

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