Cardiovascular disease in hereditary haemophilia: The challenges of longevity

被引：13

作者：

Shapiro, Susan ^{[1
,2
]}

Benson, Gary ^{[3
]}

Evans, Gillian ^{[4
]}

Harrison, Catherine ^{[5
]}

Mangles, Sarah ^{[6
]}

Makris, Mike ^{[5
,7
]}

机构：

[1] Oxford Univ Hosp NHS Fdn Trust, Oxford NIHR Biomed Res Ctr, Oxford, England

[2] Univ Oxford, Radcliffe Dept Med, Oxford, England

[3] Belfast City Hosp, Belfast, Antrim, North Ireland

[4] East Kent Hosp Univ Fdn NHS Trust, Kent Haemophilia & Thrombosis Ctr, Canterbury, Kent, England

[5] Sheffield Teaching Hosp NHS Fdn Trust, Royal Hallamshire Hosp, Sheffield Haemophilia & Thrombosis Ctr, Sheffield, S Yorkshire, England

[6] Hampshire Hosp NHS Fdn Trust, Haemophilia Haemostasis & Thrombosis Ctr, Basingstoke, Hants, England

[7] Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, S Yorkshire, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2022年 / 197卷 / 04期

基金：

英国医学研究理事会;

关键词：

ageing; atherosclerosis; cardiovascular; comorbidity; haemophilia; ischaemic heart disease; LEFT ATRIAL APPENDAGE; EMICIZUMAB PROPHYLAXIS; ANTICOAGULANT-THERAPY; BLEEDING DISORDERS; STROKE PREVENTION; LIFE EXPECTANCY; CARDIAC-SURGERY; RISK-FACTORS; FIBRILLATION; MANAGEMENT;

D O I：

10.1111/bjh.18085

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The development of effective and safe treatments has significantly increased the life expectancy of persons with haemophilia (PWH). This has been accompanied by an increase in the comorbidities of ageing including cardiovascular disease, which poses particular challenges due to the opposing risks of bleeding from haemophilia and antithrombotic treatments versus thrombosis. Although mortality secondary to coronary artery disease in PWH is less than in the general population, the rate of atherosclerosis appears similar. The prevalence of atrial fibrillation in PWH and risk of secondary thromboembolic stroke are not well established. PWH can be safely supported through acute coronary interventions but data on the safety and efficacy of long-term antithrombotics are scarce. Increased awareness and research on cardiovascular disease in PWH will be crucial to improve primary prevention, acute management, secondary prevention and to best support ageing PWH.

引用

页码：397 / 406

页数：10

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