NEMA NU 4-Optimized Reconstructions for Therapy Assessment in Cancer Research with the Inveon Small Animal PET/CT System

被引:12
|
作者
Lasnon, Charline [1 ,2 ,3 ,6 ]
Dugue, Audrey Emmanuelle [4 ]
Briand, Melanie [1 ]
Blanc-Fournier, Cecile [5 ]
Dutoit, Soizic [1 ]
Louis, Marie-helene [1 ]
Aide, Nicolas [1 ,2 ,3 ,6 ]
机构
[1] UNICANCER, Francois Baclesse Canc Ctr, BioTICLA EA 4656, Caen, France
[2] Normandie Univ, Caen, France
[3] Univ Hosp, Nucl Med Dept, Caen, France
[4] Francois Baclesse Canc Ctr, Biostat & Clin Res Dept, Caen, France
[5] Francois Baclesse Canc Ctr, Dept Pathol, Caen, France
[6] Francois Baclesse Canc Ctr, Nucl Med Dept, F-14000 Caen, France
关键词
Small animal PET; NEMA-NU; 4; Image quality; Tumor-bearing rats; Therapy assessment; EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY; RESISTANT OVARIAN-CANCER; ATTENUATION CORRECTION; IMAGE-QUALITY; PERFORMANCE EVALUATION; TUMOR XENOGRAFTS; SCANNER; MICROPET; F-18-FDG; MICE;
D O I
10.1007/s11307-014-0805-5
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
We compared conventional filtered back-projection (FBP), two-dimensional-ordered subsets expectation maximization (OSEM) and maximum a posteriori (MAP) NEMA NU 4-optimized reconstructions for therapy assessment. Varying reconstruction settings were used to determine the parameters for optimal image quality with two NEMA NU 4 phantom acquisitions. Subsequently, data from two experiments in which nude rats bearing subcutaneous tumors had received a dual PI3K/mTOR inhibitor were reconstructed with the NEMA NU 4-optimized parameters. Mann-Whitney tests were used to compare mean standardized uptake value (SUVmean) variations among groups. All NEMA NU 4-optimized reconstructions showed the same 2-deoxy-2-[F-18]fluoro-d-glucose ([F-18]FDG) kinetic patterns and detected a significant difference in SUVmean relative to day 0 between controls and treated groups for all time points with comparable p values. In the framework of therapy assessment in rats bearing subcutaneous tumors, all algorithms available on the Inveon system performed equally.
引用
收藏
页码:403 / 412
页数:10
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