Atlanta, Georgia, was the grand setting of the Fall 2021 American Chemical Society (ACS) National Meeting & Exposition, subheaded 'Resilience of Chemistry.' The meeting was both an in-person and virtual meeting at Georgia World Congress Center, and consisted of poster presentations, oral sessions, symposia, press releases and media briefings from abstracts chosen from thousands of scientific presentations on topics that include food and nutrition, medicine, health, energy, the environment, medicinal chemistry, biological chemistry, and other fields where chemistry plays a central role. Presentations were either in person or virtual, or both, allowing for an almost return to normal meeting attendance since the start of the COVID-19 pandemic, with live interaction possible in a room or online.