A biocompatible hydrogel of poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) which includes the cell-adhesive region of fibronectin Arg-Gly-Asp was synthesized and its structure, theological and dielectric properties were characterized. The ability of a PHPMA-RGD hydrogel to promote tissue regeneration and support axonal outgrowth in the injured adult and developing rat spinal cord was evaluated. The structure of the PHPMA-RGD hydrogel displayed an interconnected porous structure, with viscoelastic properties similar to those of the neural tissue, and conductivity properties due to a peptide group. The polymer hydrogel provided a structural, three-dimensional continuity across the defect, facilitating the migration and reorganization of local wound-repair cells, as well as tissue development within the lesion. Angiogenesis and axonal growth also occurred within the microstructure of the tissue network, and supraspinal axons migrated into the reconstructed cord segment. In addition, the hydrogel induced a reduction of necrosis and cavitation in the adjacent white and gray matter. These polymer hydrogel matrices therefore display the potential to repair. tissue defects in the central nervous system by enhancing the development of a tissue equivalent as well as axonal growth across the reconstructed lesion. (C) 2001 Elsevier Science Ltd. All rights reserved.
机构:
Nantong Univ, Med Sch, Nantong, Jiangsu Provinc, Peoples R China
Nantong Univ, Dept Orthoped, Affiliated Hosp, Nantong, Jiangsu Provinc, Peoples R ChinaNantong Univ, Med Sch, Nantong, Jiangsu Provinc, Peoples R China
Zheng, Jian
Chen, Ruilin
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Nantong Univ, Med Sch, Nantong, Jiangsu Provinc, Peoples R China
Nantong Univ, Dept Orthoped, Affiliated Hosp, Nantong, Jiangsu Provinc, Peoples R ChinaNantong Univ, Med Sch, Nantong, Jiangsu Provinc, Peoples R China
Chen, Ruilin
Hao, Jie
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Nantong Univ, Dept Orthoped, Affiliated Hosp, Nantong, Jiangsu Provinc, Peoples R ChinaNantong Univ, Med Sch, Nantong, Jiangsu Provinc, Peoples R China
Hao, Jie
Yang, Yang
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Nantong Univ, Affiliated Hosp, Dept Emergency Surg, Nantong, Jiangsu, Peoples R ChinaNantong Univ, Med Sch, Nantong, Jiangsu Provinc, Peoples R China
Yang, Yang
Xu, Shaohu
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Nantong Univ, Med Sch, Nantong, Jiangsu Provinc, Peoples R China
Nantong Univ, Dept Orthoped, Affiliated Hosp, Nantong, Jiangsu Provinc, Peoples R ChinaNantong Univ, Med Sch, Nantong, Jiangsu Provinc, Peoples R China
Xu, Shaohu
Zhang, Feiyu
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Nantong Univ, Med Sch, Nantong, Jiangsu Provinc, Peoples R China
Nantong Univ, Dept Orthoped, Affiliated Hosp, Nantong, Jiangsu Provinc, Peoples R ChinaNantong Univ, Med Sch, Nantong, Jiangsu Provinc, Peoples R China
Zhang, Feiyu
Zhang, Feng
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Nantong Univ, Dept Orthoped, Affiliated Hosp, Nantong, Jiangsu Provinc, Peoples R ChinaNantong Univ, Med Sch, Nantong, Jiangsu Provinc, Peoples R China
Zhang, Feng
Yao, Yu
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Nantong Univ, Dept Orthoped, Affiliated Hosp, Nantong, Jiangsu Provinc, Peoples R ChinaNantong Univ, Med Sch, Nantong, Jiangsu Provinc, Peoples R China
机构:
Univ Leeds, Inst Med & Biol Engn, Leeds LS2 9JT, W Yorkshire, EnglandUniv Leeds, Inst Med & Biol Engn, Leeds LS2 9JT, W Yorkshire, England
Golland, Ben
Tipper, Joanne L.
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Univ Leeds, Inst Med & Biol Engn, Leeds LS2 9JT, W Yorkshire, England
Univ Technol Sydney, Sch Biomed Engn, Sydney, NSW 2007, AustraliaUniv Leeds, Inst Med & Biol Engn, Leeds LS2 9JT, W Yorkshire, England
Tipper, Joanne L.
Hall, Richard M.
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Univ Leeds, Sch Mech Engn, Leeds LS2 9JT, W Yorkshire, EnglandUniv Leeds, Inst Med & Biol Engn, Leeds LS2 9JT, W Yorkshire, England
Hall, Richard M.
Tronci, Giuseppe
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Univ Leeds, Clothworkers Ctr Text Mat Innovat Healthcare, Sch Design, Leeds LS2 9JT, W Yorkshire, England
Univ Leeds, Sch Dent, St Jamess Univ Hosp, Leeds LS9 7TF, W Yorkshire, EnglandUniv Leeds, Inst Med & Biol Engn, Leeds LS2 9JT, W Yorkshire, England
Tronci, Giuseppe
Russell, Stephen J.
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Univ Leeds, Clothworkers Ctr Text Mat Innovat Healthcare, Sch Design, Leeds LS2 9JT, W Yorkshire, EnglandUniv Leeds, Inst Med & Biol Engn, Leeds LS2 9JT, W Yorkshire, England