Expression of autocrine motility factor receptor in cutaneous malignant melanoma

被引：18
|
作者：
Nagai, Y [1 ]
Ishikawa, O [1 ]
Miyachi, Y [1 ]
Watanabe, H [1 ]
机构：
[1] GUNMA UNIV, SCH MED, DEPT ORTHOPED, MAEBASHI, GUMMA 371, JAPAN
来源：
DERMATOLOGY | 1996年 / 192卷 / 01期
关键词：
autocrine motility factor receptor (AMFR); gp78; malignant melanoma; immunohistochemistry;
D O I：
10.1159/000246304
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Background: The autocrine motility factor receptor (AMFR), a specific receptor for AME is considered to be related to the metastatic potential of tumor cells, Objective: We investigated whether AMFR is expressed on cutaneous malignant melanoma cells and has any relationship to clinical stage and metastatic ability. Methods: We performed an immunohistochemical study on 20 cases of cutaneous malignant melanoma using anti-AMFR antibody. Results: AMFR was expressed in 9 cases (45%), and its expression had a tendency to correlate with the clinical stage and the presence of lymph node metastasis. Conclusions: The expression of AMFR may have a possible association with the metastatic potential of malignant melanoma.
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收藏
页码：8 / 11
页数：4
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