Aberrant activation of the mentalizing brain system during eye gaze discrimination in bipolar disorder

被引：4
|
作者：
Tso, Ivy F. [1 ]
Burton, Cynthia Z. [1 ]
Lasagna, Carly A. [1 ]
Rutherford, Saige [1 ,2 ]
Yao, Beier [3 ]
Peltier, Scott J. [4 ,5 ]
Johnson, Timothy D. [6 ]
McInnis, Melvin G. [1 ]
Taylor, Stephan F. [1 ]
机构：
[1] Univ Michigan, Dept Psychiat, 4250 Plymouth Rd, Ann Arbor, MI 48109 USA
[2] Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands
[3] Michigan State Univ, Dept Psychol, E Lansing, MI 48824 USA
[4] Univ Michigan, Funct MRI Lab, Ann Arbor, MI 48109 USA
[5] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
[6] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA
来源：
PSYCHIATRY RESEARCH-NEUROIMAGING | 2021年 / 315卷
基金：
美国国家卫生研究院;
关键词：
Bipolar disorder; Social cognition; fMRI; SOCIAL COGNITION; MIND; IMPAIRMENT; OTHERS;
D O I：
10.1016/j.pscychresns.2021.111340
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Bipolar disorder (BD) is associated with a range of social cognitive deficits. This study investigated the functioning of the mentalizing brain system in BD probed by an eye gaze perception task during fMRI. Compared with healthy controls (n = 21), BD participants (n = 14) showed reduced preferential activation for self-directed gaze discrimination in the medial prefrontal cortex (mPFC) and temporo-parietal junction (TPJ), which was associated with poorer cognition/social cognition. Aberrant functions of the mentalizing system should be further investigated as marker of social dysfunction and treatment targets.
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页数：4
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