Functional imaging of tumor vascular network in small animal models

被引：3

作者：

Kalchenko, Vyacheslav ^{[1
]}

Madar-Balakirski, Noa ^{[2
]}

Kuznetsov, Yuri ^{[1
]}

Meglinski, Igor ^{[3
]}

Harmelin, Alon ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Vet Resources, IL-76100 Rehovot, Israel

[2] Weizmann Inst Sci, Dept Regulat Biol, IL-76100 Rehovot, Israel

[3] Univ Otago, Dept Phys, Dunedin 9054, New Zealand

来源：

NOVEL BIOPHOTONIC TECHNIQUES AND APPLICATIONS | 2011年 / 8090卷

关键词：

Dynamic Light Scattering Imaging; Spectrally Enhanced Microscopy; Fluorescence Intravital Microscopy; tumor vascular network; multi-modal imaging; vascular biology; blood microcirculation; OPTICAL COHERENCE TOMOGRAPHY; BLOOD-FLOW; DOPPLER; MICROCIRCULATION; MICROSCOPY;

D O I：

10.1117/12.890746

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

In current report we present synchronized in vivo imaging of tumor vascular network and tumor microenvironment obtained by combined use of Dynamic Light Scattering Imaging, Spectrally Enhanced Microscopy, and Fluorescence Intravital Microscopy. Dynamic Light Scattering Imaging is used for functional imaging of the vascular network and blood microcirculation. Spectrally Enhanced Microscopy provides information regarding blood vessel topography. Fluorescence Intravital Microscopy is used for imaging of tumor microvasculature and tumor microenvironment. These well known modalities have been comprehensively validated in the past and are widely used in various bio-medical applications. As shown here, their combined application has great potential for studies of vascular biology. This multi-modal non-invasive diagnostic technique expands our current capacity to investigate blood microcirculation and tumor angiogenesis in vivo, thereby contributing to the development of cancer research and treatment.

引用

页数：4

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